Translation. Region: Russian Federal
Source: Novosibirsk State University –
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In the structure Institute of Medicine and Medical Technologies (IMMT) NSU A new laboratory of molecular engineering has been created; it will become the first specialized laboratory beyond the Urals that will comprehensively deal with such promising areas of modern medicine as the cultivation of microorganism cells, the study of virome and metagenomic analysis, and the prediction of protein structure based on the analysis of the data obtained.
In early 2026, after the delivery of the new building of the NSU IMMT, which is part of the second stage of the NSU campus, built within the framework of the national project "Youth and Children", the laboratory will be located on the premises of the new campus. The creation of the laboratory is part of the strategic project "Center for the Integration of Personalized Biomedicine, Pharmacy and Synchrotron, Binary Technologies", financed within the framework of Priority 2030 programs.
Currently, the laboratory employs 5 people, including representatives of leading research centers in Novosibirsk and Tomsk. Also, students, postgraduates and graduate students of the Institute of Medicine and Medical Technologies, the Faculty of Natural Sciences and other faculties of NSU will be involved in the work in the laboratory, who, as part of the preparation of their diploma and scientific papers, will participate in the implementation of the laboratory's projects. The laboratory is headed by Elena Prokopyeva, PhD in Biology, research fellow at the IMMT NSU.
The laboratory is fully focused on solving applied problems facing the modern pharmaceutical industry and biomedicine. First of all, we are talking about the rapid implementation of new methods of pharmaceutical development, expansion of interdisciplinary research, integration of artificial intelligence and big data analysis in biology and medicine; as well as the formation of a modern educational environment for training new generation specialists, including students from different countries.
The main areas of work of the laboratory:
creation and improvement of biotechnological protocols for cultivating prokaryotic and eukaryotic microorganisms in laboratory and industrial bioreactors; creation of innovative methods for identifying and quantitatively analyzing viral particles using accelerator mass spectrometry; study of the diversity, structure and dynamics of viral communities (virosphere) in various ecological niches using modern methods of metagenomics and bioinformatics.
— One of the promising areas for the laboratory is the analysis of viromes (a set of viruses) using metagenomic and bioinformatics analysis in partnership with research institutes of the Siberian Branch of the Russian Academy of Sciences. This is an advanced area in science. Metagenomic analysis is based on next-generation sequencing methods, which can be used to “read” several sections of different genomes in different samples at the same time. However, today the problem is the analysis of billions of available sequences, the number of which increases exponentially every year. Thus, advanced technologies will speed up the process of identifying new viruses, even based on already available and published metagenomic data, — said Elena Prokopyeva.
The lab plans to use machine learning models to analyze biomedical data, such as genomic, transcriptomic, and proteomic data, as these methods can effectively identify complex patterns and relationships in large and multidimensional data sets. The use of machine learning in biomedical research opens up new opportunities for deep understanding of biological processes and improving clinical practice.
Another area of the laboratory's work is education. By the end of 2025, an interactive educational web application will be finalized. HTTP: //histology. HSU.ru, which includes a collection of digital microscope slides on histology, embryology and cytology.
— Thus, this project will create a comprehensive scientific and technical platform that will unite disparate areas (bioreactors, metagenomics, molecular diagnostics, digitalization of education and biomedical developments) into a single ecosystem, increase the efficiency of research and accelerate the introduction of innovations in industry and medicine, — Elena Prokopyeva emphasized.
The industrial and scientific partners of the laboratory are industry leaders — Technoprom LLC, research institutes of the SB RAS (G.I. Budker Institute of Nuclear Physics SB RAS, G.K. Boreskov Institute of Catalysis SB RAS, Federal Research Center Institute of Cytology and Genetics SB RAS), FBSI SRC VB Vector of Rospotrebnadzor, Federal Research Center for Fundamental and Translational Medicine (FRC FTM). The laboratory also cooperates with foreign partners, such as Qinghai University and East China Normal University (China), RSE Institute of Genetics and Physiology (Kazakhstan).
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