Financial news: 08/28/2025 JSC “KAVKAZ.RF” will hold a deposit auction.

Translation. Region: Russian Federal

Source: Moscow Exchange – Moscow Exchange –

An important disclaimer is at the bottom of this article.

Parameters;

Date of the deposit auction 08/28/2025. Placement currency RUB. Maximum amount of funds placed (in the placement currency) 314,000,000. Placement term, days 88. Date of depositing funds 08/29/2025. Date of return of funds 11/25/2025. Minimum placement interest rate, % per annum 16.25. Terms of the conclusion, urgent or special (Urgent). Minimum amount of funds placed for one application (in the placement currency) 314,000,000. Maximum number of applications from one Participant, pcs. 1. Auction form, open or closed (Open).

The basis of the Agreement is the General Agreement. Schedule (Moscow time). Preliminary bids from 10:00 to 10:10. Competitive bids from 10:10 to 10:15. Setting the cutoff percentage or declaring the auction invalid before 10:25. Additional terms.

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

Financial news: 08/27/2025, 16-38 (Moscow time) the values of the upper limit of the price corridor and the range of market risk assessment for the security RU000A1098W8 (DOM 1P-18R) were changed.

Translation. Region: Russian Federal

Source: Moscow Exchange – Moscow Exchange –

An important disclaimer is at the bottom of this article.

08/27/2025

16:38

In accordance with the Methodology for determining the risk parameters of the stock market and deposit market of Moscow Exchange PJSC by NCO NCC (JSC) on August 27, 2025, 16:38 (Moscow time), the values of the upper limit of the price corridor (up to 105.61) and the range of market risk assessment (up to 1305.24 rubles, equivalent to a rate of 10.0%) of the security RU000A1098W8 (DOM 1P-18R) were changed.

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

Financial news: 08/27/2025, 15:53 (Moscow time) the values of the upper limit of the price corridor and the range of market risk assessment for the SU26231RMFS9 security (OFZ 26231) were changed.

Translation. Region: Russian Federal

Source: Moscow Exchange – Moscow Exchange –

An important disclaimer is at the bottom of this article.

08/27/2025

15:53

In accordance with the Methodology for determining the risk parameters of the stock market and deposit market of Moscow Exchange PJSC by NCO NCC (JSC) on August 27, 2025, 15:53 (Moscow time), the values of the upper limit of the price corridor (up to 14:43) and the range of market risk assessment (up to 166.47 rubles, equivalent to a rate of 50.0%) of the SU26231RMFS9 security (OFZ 26231) were changed.

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

Sergei Sobyanin summed up the results of Moscow International Film Week

Translation. Region: Russian Federal

Source: Moscow Government – Government of Moscow –

An important disclaimer is at the bottom of this article.

The first two applications for rebates have been submitted at Moscow International Film Week. This is the name given to compensation for part of the costs incurred during the filming of international projects in the Russian capital. Sergei Sobyanin reported this on his channel in messenger MAX.

"A feature film about badminton will be created together with Indian partners. And together with Uzbek filmmakers, we will immortalize the memory of the Tashkent division, which took part in the heroic battle for Moscow," noted Sergei Sobyanin.

Source: Sergei Sobyanin's channel in messenger MAX

In addition, agreements were signed with Egypt, Mexico, Brazil and Turkey. They agreed to study the experience in developing urban film clusters and stimulate the exchange of film crews between countries.

Other important events of the film week included the launch of the Moscow film truck, a unique mobile cinema with a screen built into the back of a car. It moved around various venues and showed domestic films and foreign films from Italy, France, the USA, Germany, Serbia and other countries.

Russian film companies became part of the Moscow charity project “City of the Caring”, together with which they held a film auction.

And of course, there were many film screenings, autograph sessions, meetings with stars and famous guests, including directors Woody Allen and Emir Kusturica.

Moscow International Film Week has ended. The largest cinematic event brought together about 200 events and more than 700 thousand guests. It is expected that next year it will be no less large-scale and memorable.

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

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Sergei Sobyanin announced the completion of the second stage of the Moskino cinema park

Translation. Region: Russian Federal

Source: Moscow Government – Government of Moscow –

An important disclaimer is at the bottom of this article.

Sergei Sobyanin inspected the Moskino cinema park and met with directors and producers working on film sets.

Konstantin Ernst (who is filming the movie "Lilya"), Danila Sharapov ("Secret City"), Dmitry Kiselev ("Russian Troika"), Fyodor Bondarchuk ("Hard to Be a God"), Mikhail Vrubel ("Buratino"), Sergei Zhigunov ("Breed"), Leonid Vereshchagin ("Queen Anna"), Igor Ugolnikov (films about domestic wars of different times) told the Mayor of Moscow about their projects.

"Congratulations on your professional holiday – Russian Cinema Day. As a classic said, this is the most important of all arts. And I am very glad that it is demonstrating such a fantastic pace of development. In recent years, both the volume of content and the number of viewers who watch Russian cinema have simply increased several times. I think that this is the most important result of our work. It is clear that cinema today is not only entertainment: it is ideology, and education, and promotion, and therefore what you are doing is simply wonderful. I am very grateful to you, tens of thousands of cinema workers who produce and work on Russian cinema art," the Moscow Mayor noted.

Sergei Sobyanin emphasized that the city, for its part, is doing everything to ensure that Moscow confirms its status as the Russian capital of cinema and that it also becomes the capital of world cinema.

"At least the infrastructure that we are creating together is already world-class. Last year, Vladimir Vladimirovich and I opened the first stage of the park

"Moschino". I must report that in a year we have doubled the capacity of the Moskino sites. This is an opportunity to shoot amazing, unique films and TV series. In addition, you know that we are reviving the Gorky Studio. Enormous capital works are being carried out there. The volume of pavilions will double – these will be completely new, modern pavilions. The Moscow Film Factory, Moskino – is already a huge site with a large number of pavilions, which is developing dynamically," added Sergei Sobyanin.

For film industry professionals

The largest media groups in Russia are implementing their projects in the cinema park: National Media Group, Gazprom-Media Holding, USM Holdings, Channel One, All-Russian State Television and Radio Broadcasting Company, Sber.

"Thank you for creating this unprecedented platform at an absolutely global level. Moscow confirms yet another of its hypostases as a world leader, now in the field of film production. And thanks to Moskino, I think that Russian cinema will reach the next level of its development. This would be impossible without Moscow's help," said Konstantin Ernst.

The following series were filmed in the cinema park: Princess Olga, Arsenyev, Moscow Does Not Believe in Tears. It's Just Beginning, Admiral Kuznetsov, And in Our Yard – 3, GDR, Krasnov. New Episodes, At the Call of the Heart, The Enemy at the Gate, Drilling Rig, The Sovereign, Patriot-4, SMERSH-3. Completed feature films include The Ninth Planet, Santa Claus Is Wanted, Not on the Lists, Aldan, War and Music, Home Alone. The Magnificent Five, Knock on My Door in Moscow, Letter to Santa Claus, Baba Yaga Saves the New Year, Darling, I Won't Call Back Anymore.

For filming, 34 locations were built in the 356-hectare cinema park, including "Yurovo Airport", "Vitebsk Railway Station", "Old Russian City", "Cathedral Square of Moscow", "City Yard", "Moscow in the 1940s", "Center of Moscow", "County Town of Russia", "Cowboy Town", "Moscow during the Constructivism Period", "Modern Moscow", "Cities of the Middle East and Central Asia", "Provincial Cities of Europe" and others. In addition, six pavilions and six infrastructure facilities were built.

Each of the sets is used by different film studios to implement a variety of projects. You can book the site online through Moscow Film Platform.

A natural chromakey has been created in the cinema park. It is needed for filming using computer graphics. If necessary, a Tu-154 aircraft can be installed here.

The immediate plans include completing the construction of at least 10 sets, including the Fortress, Cities of Eastern Europe, Fairytale City and others. In addition, the film park will build two more multifunctional pavilions with an area of 4.6 thousand square meters and a working ceiling height of up to 24 meters, as well as a warehouse complex, a multi-level parking lot and a hotel complex with more than 200 rooms.

Early 20th century buildings recreated in Moskino cinema park for filming of TV series LilyaLight and Shadow: How Lighting Designers Create Atmosphere on Film Sets

For everyone who loves cinema

In addition to the filming infrastructure, the cinema park has created comfortable conditions for visitors and tourists. They can use the hotel and restaurant services, visit the museum and visit the festival sites. The cinema park is open to everyone on weekends and holidays. Thematic excursions and quests are held for guests as part of the "Cinema Weekend" project. Visitors can inspect the scenery if they are not involved in the filming process at that time.

The Vadim Zadorozhny Museum of Technology is open – a unique combination of automobile history and cinematic heritage. Viewers can see more than 50 units of technology – these are cars that have become an integral part of Russian culture, as well as famous foreign models.

In 2024–2025, the cinema park hosted major events, including the festival of historical reconstructions “Times and Epochs”, the gastro festival “Golden Autumn”, Eduard Boyakov’s multimedia production “Cathedral Square”, Igor Ugolnikov’s immersive performance “Moscow Speaking! Battle for Moscow. First Victory”, the International Festival of Stunt Art, the Moscow Festival of Animation and Children’s Cinema, the music festivals “Straw” and “Ours in the City”, and other events.

Since its opening, over 530 thousand people have visited the cinema park on weekends and holidays.

Moscow Film Industry

There are more than 3.6 thousand film studios, production centers and media holdings operating in Moscow. Up to 90 percent of Russian content is produced in the capital.

After the departure of foreign giants in 2022, a vacuum appeared that domestic producers and online platforms began to fill. In total, during this period, the capital's film studios earned 342 billion rubles in revenue. Profit amounted to about 31 billion rubles.

The financial performance of Moscow film companies grew steadily from 2022 to 2024. During this period, their revenue almost doubled, and their profit more than doubled. The most successful year was 2024, which brought in 143 billion rubles in revenue and 14.7 billion rubles in profit. This is almost half of the combined figures for three years.

Thus, the market is successfully recovering from the introduction of sanctions and is showing steady growth.

The Moscow government is implementing a large-scale project, "Moscow — City of Cinema". It includes the modernization of existing facilities and the creation of new infrastructure, as well as the development of special services to increase the production of high-quality international-level film content.

More than 140 projects have already been filmed on the sites of the Moscow film cluster.

The Moscow film cluster includes:

— Moskino cinema park in TiNAO — a complex for outdoor location filming;

— Gorky Film Studio, which is currently experiencing a second birth;

— the Moskino film factory on Ryazansky Prospekt is a modern full-cycle film and media cluster;

— the Moskino cinema chain.

In addition, the cluster includes the Moskino digital film platform and the Moskino film commission.

Gorky Film Studio is one of the oldest Russian film companies. Many of its films have entered the golden collection of Russian and world cinema.

At the end of 2023, the film studio became the property of Moscow. The city decided to carry out a large-scale modernization of both its sites. As a result, the total area of the Gorky Film Studio will more than double – up to 100 thousand square meters. The main work is planned to be completed in the fourth quarter of 2025.

A new studio and production complex is being built on the site at Valdaisky Proezd (building 16). It will house 10 modern technological filming pavilions, screening rooms, virtual set design studios, editing and color correction, motion capture, as well as dressing rooms and other necessary premises. The specifics of the pavilions with large-span structures up to 42 meters wide, 12 to 22 meters high and soundproofing provide ample opportunities for filming.

The new studio will include a visual technology center. It will specialize in providing a full range of video production services — from multi-camera shooting and color correction to 3D modeling and projects with virtual and augmented reality in 4K format. The center’s capabilities will allow for the production of content in real time and the creation of world-class projects.

Six new studios have opened on the historic site on Sergei Eisenstein Street. They are suitable for creating digital content and are therefore very popular among the blogging community. At the moment, the studios are 100 percent full. Two more digital studios will open at the end of 2025.

In addition, a virtual production pavilion, "55.8 Gorky Virtual Studio", has been opened. Thanks to unique technologies and large LED screens, it is possible to create content on any background and reduce filming time several times. The pavilion is currently located in the Moscow International Business Center "Moscow-City", but after the completion of the modernization of the historical site, the virtual studio is planned to be moved to one of the built filming complexes.

Since the Gorky Film Studio became the property of the Moscow Government, 20 films have already been shot there. Among them are the feature films Chizhik-Pyzhik Returns, How I Met Her Mother, Tour with Ivanushki, Vera, as well as the non-fiction films Gorbacheva, Territory of Attachment, and Through Dark Matter. More than 20 feature and non-fiction projects are at various stages of development and production.

In 2023, the Gorky Film Campus opened — a creative space for career guidance for children and teenagers in the field of cinema and media. The film campus is equipped with modern high-tech equipment, including a studio with a cyclorama and chromakey background, a sound recording studio, editing rooms, and a screening room.

The Moskino Film Factory is a large creative space on Ryazansky Prospekt. It is the first inter-industry center of full-cycle creative industries, uniting filmmakers, representatives of fashion, design, music and media, as well as IT specialists.

Currently, the film factory employs:

— four filming pavilions, allowing filming with construction to meet any request from film companies;

— two XR pavilions with the ability to shoot on LED screens with augmented reality technology;

— thematic pavilion "Police".

Soon, pavilions for free construction, with a cyclorama, as well as two pavilions with permanent interior decorations of a hospital and an apartment will be opened.

In addition, the Moskino film factory houses Europe's largest costume and props center, the Firebird. It supplies props for more than 80 percent of the country's filming projects.

In March 2025, the film factory presented a unique for Russia design of LED screens, or "washer", with an area of over 300 square meters. This allows creating unique scenes using virtual production technology and filming movies of any complexity directly in the pavilions.

With the participation of the Moskino film factory, 52 different format film projects have been implemented. Among them are The Last Bogatyr. Legacy, Chelyuskin. The First, The First Number, Sklif and Major Grom. In 2025, the filming of more than 70 projects is planned.

The Moskino Film Commission was created in 2018. Its main goal is to increase the presence of the capital, its streets, parks and cultural heritage sites on big screens, as well as to attract the attention of filmmakers to the infrastructure of the Moscow film cluster.

With the help of the Moskino film commission, producers receive permits to film in Moscow, including work on the street and road network. Since 2023, applications have been accepted only through the Moskino film platform. Producers can receive a filming permit within seven working days. It may take up to 50 working days to approve complex projects, including those using pyrotechnics, fake weapons, and special effects.

With the support of the Film Commission, more than a thousand projects were created in 2024–2025. Among them are the full-length films The Master and Margarita, Kholop-2, The Flying Ship, Ice-3, and the popular TV series Games, CyberVillage, Vampires of the Middle Lane, The Word of a Boy. Blood on the Asphalt, Kidney (second and third seasons), and Daddy's Daughters. New. In recent years, views of the capital have been filmed in such projects as At the Call of the Heart, Challenge, Actresses, and Knock on My Door.

One of the important areas of work of the capital's film commission is assistance in filming works by students of specialized universities. Among them are the All-Russian State Institute of Cinematography named after S.A. Gerasimov, the Institute of Cinema and Television, the Moscow School of New Cinema, the S.F. Bondarchuk Film School, and the Higher Courses for Scriptwriters and Directors named after G.N. Daneliya. Thanks to the assistance of the film commission, more than 80 student works have been filmed since the beginning of 2025.

The Moskino cinema chain traces its history back to 1932, when by order of the presidiums of the Moscow City Executive Committee and the Moscow City Council, the Mosgorkino Moscow City Cinema Trust was formed.

Today, the Moskino network carries out cultural and educational activities. It provides viewers of all ages with the opportunity to watch not only entertaining films, but also art films, Soviet films and rare film classics on the big screen. In addition, the network supports capital film festivals and organizes its own events.

Currently, there are 15 cinemas in the Moskino network. Each of them has its own unique atmosphere and attracts movie lovers. In 2024–2025, the network will include the library with the Moskino Zhukovsky cinema hall, the Moskino Angara cinema in the Angara Meeting Place district center, and the Moskino Kinopark cinema in the Moskino Cinema Park in TiNAO.

New measures to support film producers

During a visit to the Moskino cinema park, Sergei Sobyanin announced a new measure of financial support for film producers.

"The city will also help the film industry financially – it will compensate up to 70 percent of the costs of advertising in the capital, up to five million rubles. Producers of films and cartoons for children and teenagers and authors of projects that reflect the traditional spiritual and moral values of our country can apply for this measure of support," he wrote in his channel in the messenger.

Max Sergei Sobyanin.

Source: Moscow Mayor's channel in messenger Max 

The maximum amount of support is five million rubles.

In addition, the next stage of collecting applications for grants for creating the image of Moscow in cinema has opened. The maximum grant amount is 20 million rubles. This city support measure has been in effect since 2020.

Applications are now open for a grant to promote the image of Moscow in cinemaHow interiors are created for filming on location at the Moskino cinema park

Results of the Moscow International Film Week

From August 23 to 27, 2025, the capital hosted the second Moscow International Film Week, which was attended by over 700 thousand people. The event was attended by 150 speakers from more than 20 countries – representatives of film companies, producers, scriptwriters and government officials. Over 200 meetings of various formats were held at various venues in Moscow – from film screenings to a charity film auction.

As part of the Moscow International Film Week, two Moscow companies signed agreements with foreign filmmakers on joint work on new projects. Thus, the film "Smash", dedicated to badminton, will be worked on by OOO "Film Company "Smena"" and Kartina Entertainment and Sports Private Limited (India). The project about the feat of the Tashkent Division in the Battle of Moscow will be implemented by OOO "KD Studios" and the film concern "Uzbekfilm".

Both international projects have applied for financial support from the city to film in Moscow.

Four agreements on film cities were signed at the Moscow International Film Week. Moscow's partners were the Egypt Film Commission (Cairo), Mexico City Film Commission (Mexico City), RioFilme (Rio de Janeiro) and the Tesiyap Turkish Producers Association (Istanbul). It is expected that there will be an exchange of experience between film ecosystems of different countries, discussion of best practices, joint development of projects and the formation of sustainable strategic ties.

The parties also undertake to stimulate international exchanges of film crews, which will allow Moscow to attract even more international film companies.

Moscow International Film Week to Bring Together Representatives from 21 CountriesMore than 50 thousand people took part in the events of the Moskino cinema park in July

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

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Schedule of ceremonies for the initiation of first-year students into RUDN students in 2025

Translation. Region: Russian Federal

Source: Peoples'Friendship University of Russia –

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Tricolor unites: RUDN celebrated the Day of the State Flag of Russia

On the Day of the Russian National Flag, RUDN University was very lively. To the sounds of the song "Mother Earth" and other compositions about love for the homeland, students of our university decorated their faces with the flags of their countries: Costa Rica, Suriname, Vietnam, Columbia, Brazil and many others. And almost everyone asked to draw the Russian flag for themselves at the same time.

White-blue-red: how and when the Russian flag appeared

On August 22, Russia celebrates National Flag Day. In honor of the holiday, we decided to talk to the head of the Russian History Department of the Faculty of Humanities and Social Sciences at RUDN University, Elena Kryazheva-Kartseva, and find out when the tricolor appeared, who created it, and what other flags our country has had.

Youth, education and love: a RUDN student learned about her main values thanks to the program “Live and create in Russia”

Have you ever thought about what it means to “live”? This is the question that the participants of the second season of the educational program “Live and Create in Russia” of the All-Russian student project “Your Move” were asked to reflect on. Among them was RUDN student Anastasia Bogoyavlenskaya.

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

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New courses have been prepared at the Youth of Moscow Academy for the start of the academic year

Translation. Region: Russian Federal

Source: Moscow Government – Government of Moscow –

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The Moscow Youth Academy has opened recruitment for a new stream. Participants will gain knowledge and skills in digital technologies and creative industries. The first classes will be held on September 6. This was reported by Natalia Sergunina, Deputy Mayor of Moscow.

"Six free courses in modern areas have been prepared for students. For example, students will be introduced to the basics of Internet marketing and told how to use neural networks in their work. Students can choose one or several programs at once," said Natalia Sergunina.

The training will be conducted in a blended format – both online and in person.

The course "Contentmaker. Basic Level" will be devoted to the creation of text and video materials for websites and social networks, taking into account current trends. Experts will analyze each step step by step – from the idea to editing.

The program “Neural Networks: From Theory to Practice – Tools for the Future” will focus on the use of digital assistants in various fields.

Marketers will be offered to study various analytics systems and methods of their application, and then will be helped to develop and implement a personalized promotion strategy. Beginning designers will be given recommendations on how to assemble a website on a popular platform.

Tips on preparing a stage speech and overcoming the fear of public speaking will be useful for representatives of any profession.

Applications for participation are open from official websiteof the project "Youth of Moscow". Graduates will receive certificates of completion of the course.

The Academy was created jointly with the Technograd Innovation and Educational Complex at VDNKh, and opened this spring. The first cohort brought together 735 aspiring specialists.

Quickly find out the main news in the official channels of the city of Moscow in messengers MaxAnd "Telegram".

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

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City residents can purchase plots for the construction of private homes in the Troitsky District of the capital

Translation. Region: Russian Federal

Source: Moscow Government – Government of Moscow –

An important disclaimer is at the bottom of this article.

Individuals can purchase land for individual housing construction in Moscow directly from the city. A plot for individual housing construction (IHC) can be selected from a special city list atmos.ru portal. Currently, it presents 30 objects in the Troitsky Administrative Okrug (TAO). This was reported by the Deputy Mayor of Moscow for Urban Development Policy and Construction Vladimir Efimov.

"In the Troitsky Administrative District, Muscovites can purchase almost 3.3 hectares of land for the construction of private residential buildings with a total area of over 13 thousand square meters. Thus, the special list includes 30 plots for individual housing construction, located in the Tatar Administrative District. Anyone can choose a suitable property and submit an application for its purchase to the Department of City Property. If there are two or more applicants, an auction will be held. The plots are located in 12 settlements of the district, each of them has its own logistical and infrastructural advantages," commented Vladimir Efimov.

After selecting a free plot of land from a special list, a city resident – an individual must submit an application for its purchase to the capital Department of City PropertyIf no new applications for the purchase of the property are received within 30 days, a purchase and sale agreement will be concluded with the applicant.

The properties available for purchase are located in the villages of Kamenka, Popovka, Vlasovo, Rogovo, Vasyunino, Klenovka, Meshkovo, Kuznetsovo and Belousovo. In addition, there are vacant areas in the villages of Klenovo, Voronovo and Mikhailovo-Yartsevskoye.

"In the village of Klenovo in the Voronovo district, six plots with a total area of over 0.6 hectares are available for purchase. The properties are located four kilometers from the Varshavskoye Highway and less than 10 kilometers from the Central Ring Road. In the village of Meshkovo in the same district, three properties with a total area of almost 0.3 hectares can be purchased, and three more plots of land with a total area of over 0.2 hectares are located in the village of Kuznetsovo in Bekasovo," she noted.

Ekaterina Solovieva, Minister of the Moscow Government, Head of the Moscow Department of City Property.

Information about land plots put up for auction is published onMoscow investment portalSubmission of an application, participation in the bidding and conclusion of the contract takes place online.

Development of electronic services for business corresponds to the objectives of the national project "Data Economy and Digital Transformation of the State".

Quickly find out the main news in the official channels of the city of Moscow in messengers MaxAnd"Telegram".

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

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"Youth of Moscow" to hold family quest and master classes on Bolotnaya Square

Translation. Region: Russian Federal

Source: Moscow Government – Government of Moscow –

An important disclaimer is at the bottom of this article.

On August 29, the Youth of Moscow project will organize quest for the whole family on Bolotnaya Square. It will be held from 12:00 to 20:00 at the festival sites "Youth Point" and will become part of the project "Summer in Moscow". The tasks will help to unite families and reveal the creative potential of each participant.

"Youth Point" is a space where children, young people, and adults can express themselves in different directions. A family quest is a great opportunity not only to have fun and usefully spend time, but also to truly unite and reveal their talents," noted Margarita Savinkina, head of the Youth of Moscow project.

The quest will include five stations. Everyone who completes the tasks will be able to receive a branded gift and participate in the drawing of the main prize – scooters.

At the “Creative” station, you need to create an image of a family on the interactive light panel, and at the “Sport” site, you need to play mini-golf and drive the ball into the hole.

The Development hub will host master classes. At 2:00 PM, guests will make a florarium — a miniature garden with artificial plants and moss in a glass vessel. At 3:00 PM, specialists will explain how to properly grow microgreens. They will talk about types of seeds, sowing methods, plant care, and harvesting. At 6:00 PM, participants will create a three-dimensional panel called “Favorite Pet” from airy plasticine.

At the next site, the teams will draw their dream house with chalk. At the last station, they will play Twister and test their agility and coordination.

You can pick up a branded gift on the veranda of the main pavilion of the festival. The drawing of scooters will take place at the rollerdrome at 20:10. To participate, you need to go through all the stations and leave a leaflet with a phone number for the organizers.

More opportunities for young Muscovites can be found on the portal "Youth of Moscow" and project pages insocial networks.

"Summer in Moscow"— the main event of the season. The project is aimed at strengthening social and family ties, as well as the personal development of its participants. Thanks to a variety of programs, including educational, cultural and sports events, it unites Muscovites and guests of the city of different ages, social groups and creates conditions for obtaining new knowledge, creative growth and an active lifestyle.

Quickly find out the main news in the official channels of the city of Moscow in messengers Max And"Telegram".

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

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Protecting the brain from dementia: SPbPU scientists propose a new method of treating Alzheimer's disease

Translation. Region: Russian Federal

Source: Peter the Great St. Petersburg Polytechnic University –

An important disclaimer is at the bottom of this article.

Researchers from the Institute of Biomedical Systems and Biotechnology of Peter the Great St. Petersburg Polytechnic University (SPbPU) have proposed a new strategy to combat Alzheimer's disease. The results of their work were published in the prestigious international journal The Journal of Neuroscience.

Alzheimer's disease remains one of the most common and devastating neurodegenerative diseases in the world.data According to the World Health Organization, 57 million people worldwide suffer from dementia, with 60–70% of cases suffering from its most common form, Alzheimer's disease. As scientists note, this disease is caused by harmful substances accumulating in the brain: β-amyloid, which forms plaques, and tau protein, which curls into balls. This interferes with the normal functioning of nerve cells, disrupts the connection between them, and gradually leads to deterioration of memory and thinking. Modern therapeutic approaches are mainly associated with attempts to remove these plaques from the brain, but in practice they do not show high efficiency.

SPbPU scientists focused on another fundamental problem accompanying Alzheimer's disease — the imbalance of calcium ions inside neurons. As the authors of the study explain, calcium plays the role of a key signaling element in nerve cells. Normally, its concentration inside the cell is strictly controlled. In Alzheimer's disease, toxic β-amyloid disrupts this regulation, causing a massive and uncontrolled flow of calcium into neurons. Calcium overload leads to cell hyperactivity, disruption of neural connections and, ultimately, to their death, which is manifested by loss of memory and cognitive functions. Instead of blocking calcium channels (an approach that often leads to serious side effects), scientists proposed helping the cell cope with the problem itself. Their attention was drawn to the intracellular SERCA pump, which is responsible for pumping excess calcium into special storage facilities. The hypothesis was that enhancing the work of this pump could protect neurons from calcium stress.

In the first stage, the researchers tested six substances that could potentially activate the SERCA pump. Using cell models with a fluorescent calcium sensor, they identified the most effective compound, NDC-9009. Not only did it normalize calcium levels in neurons better than others, but it also protected them from the damaging effects of β-amyloid, preserving the integrity of dendritic spines, structures that are critical for memory formation. Having confirmed its effectiveness in cell models, the scientists moved on to testing on mice with an Alzheimer's disease model. To monitor brain function in real time, they used cutting-edge technology — miniscopeIt is a miniature microscope that is attached to the head of a freely moving rodent and allows the activity of hundreds of neurons to be recorded simultaneously, for example in the hippocampus, the brain's memory center.

Mice with Alzheimer's disease showed chaotic and excessive neuronal activity. After a course of intraperitoneal administration of NDC-9009, the activity of their neural networks normalized, becoming similar to that of healthy animals. More importantly, this restoration of brain function was accompanied by a clear improvement in memory and learning ability in behavioral tests. The analysis of data obtained from the miniscope was carried out using software we developed earlier NeuroactivityToolkit, — explained Evgeny Gerasimov, a research engineer at the Laboratory of Molecular Neurodegeneration and the Laboratory of Biomedical Image and Data Analysis at SPbPU.

These results indicate that SERCA pump modulators, and NDC-9009 in particular, offer a promising new avenue for the treatment of Alzheimer's disease. This approach targets a fundamental mechanism of cell death, calcium imbalance, and may have a more favorable safety profile than existing therapies.

The work was completed by a team of authors: Evgeny Gerasimov, Anastasia Rakovskaya, Ekaterina Pchitskaya, Olga Vlasova, Dal Russell and Ilya Bezprozvanny within the framework of project No. 075-15-2024-548 in priority areas of scientific and technological development of the Ministry of Science and Higher Education of the Russian Federation.

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