Category: Moscow

Translation. Region: Russian Federation –

Source: Peter the Great St. Petersburg Polytechnic University –

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On November 27, a plenary session entitled "Big Challenges: Impetus for Development" was held at the Sirius University of Science and Technology. The event, timed to coincide with the 80th anniversary of Russia's nuclear industry, brought together leading experts in science and technology. Andrey Rudskoy, Rector of Peter the Great St. Petersburg Polytechnic University, participated in the session.

The meeting discussed strategic directions for the development of Russian science and the role of the nuclear industry in the country's technological sovereignty. Participants paid particular attention to training personnel for high-tech industries and developing scientific infrastructure. St. Petersburg Polytechnic University has traditionally been a key source of personnel for the nuclear and other industries, and the university's research finds application in various sectors of the economy.

"The Congress of Young Scientists is an important platform for shaping the scientific agenda," noted the SPbPU rector. "Participation in such events allows us not only to stay abreast of the latest trends but also to assess the prospects for integrating university science into solving major technological challenges."

At the Polytechnic University stand, Rector Andrey Rudskoy discussed projects presented by the Student Scientific Society (SSS) and the Council of Young Scientists (CYS) with students, postgraduate students, and young scientists.

These initiatives need to be developed and boldly brought to the implementation stage. The future of science belongs to you: students, graduate students, and young researchers. Your energy and innovative approach are the main resource for scientific discoveries," the university's director encouraged the young innovators.

The Student Research Community provides students with their first research experience, putting their academic theories to the test. The Council of Young Scientists is a community of graduate students, engineers, and researchers under 35 who not only conduct their own projects but also help their colleagues apply for grants, organize scientific seminars, and coordinate interdisciplinary work.

During the Congress of Young Scientists, the Polytechnic University's stand brought together projects where fundamental science addresses specific challenges facing industry and society, and became a platform for open dialogue where young scientists discussed their projects and promising ideas.

Polytechnicians and invited speakers demonstrated how their research influences development in a wide range of fields, from energy to history.

Oleg Shmakov, Associate Professor at the Higher School of Automation and Robotics at the Institute of Mechanical Engineering, Materials, and Transport and project manager for the Priority 2030 program, presented a robotic system for gas pipeline diagnostics.

"The length of our main pipelines exceeds 170,000 kilometers," the scientist explained. "The robots we've developed allow for their effective monitoring, preventing accidents."

Irina Anikina, Associate Professor at the Institute of Power Engineering's Higher School of Nuclear and Thermal Energy, demonstrated how digital technologies are transforming the industry. Her team is creating digital twins of power equipment that "learn" from sensor data.

These models don't just describe an asset; they account for its wear and tear in real time. This allows for predicting breakdowns and optimizing repair schedules, Anikin noted.

Konstantin Semenov, Associate Professor at the Higher School of Computer Technology and Information Systems at the Institute of Computer Science and Cybersecurity, proposed examining the very nature of measurement. His paper, "Absolutely Precise Measurements Are a Coarsening of Reality," explores how error affects our understanding of the world and why striving for perfect accuracy can be a simplification.

Zoya Korobova, Chair of the Council of Young Scientists at the Pasteur Research Institute of Epidemiology and Microbiology in St. Petersburg and a researcher in the Laboratory of Molecular Immunology, discussed the new role of the immune system.

Today, we see that immunity is not just a protector, but a key regulator of most processes in the body. Studying it opens up new possibilities for treating a wide range of diseases, the researcher said.

Natalia Morozova, Associate Professor at the Institute of Biomedical Systems and Biotechnology, Higher School of Biotechnology and Food Production, presented a paper titled "Tools and Methods of Genome Editing," highlighting the current opportunities and challenges in this rapidly developing field. She also detailed examples of successful applications of CRISPR-Cas technologies to address challenges in biotechnology and medicine.

Ekaterina Pchitskaya, Head of the Biomedical Image and Data Analysis Laboratory at the Institute of Cardiology and Biophysics, presented a paper titled "Artificial Intelligence for Studying the Natural: Synapses, Neural Networks, and Behavior." The scientist demonstrated how machine learning methods can decipher complex processes occurring in the nervous system and link neuronal activity to behavioral events.

Tatyana Koryakovtseva, Associate Professor at the Higher School of Hydraulic and Power Engineering at the Civil Engineering Institute, conducted a study on the concrete of the future. Scientists are incorporating synthetic and natural materials into traditional concrete to create stronger and warmer building composites. The project includes an environmental assessment of the materials, enabling the selection of not only effective but also sustainable solutions.

Ilya Sidorchuk, a professor at the Higher School of International Relations at the Humanities Institute, took the audience into the world of suburban science.

"The history of suburbs helps us understand how modern urban life was shaped," the professor believes. "By studying the everyday lives of residents, we see that the city is a complex organism where the interests of people, government, and nature are intertwined."

Lyudmila Dorofeeva, Senior Researcher at the Institute of Regional Economic Problems of the Russian Academy of Sciences and Chair of the Council of Young Scientists and Specialists, spoke about the practical implementation of these developments. She presented a unique continuing education program, "Qualified Customer – Qualified Contractor," which Polytechnic University is implementing in collaboration with academic and industrial partners.

We train specialists who are able to intelligently set scientific goals and understand how to apply their results in the real sector, Dorofeeva explained.

The Polytechnic University's scientific program, presented at the stand, demonstrates how the university creates an environment where engineering solutions, historical analysis, and biomedical research combine to offer answers to complex modern challenges.

Recognized experts also spoke at the Polytechnic University stand: Corresponding Member of the Russian Academy of Sciences Nikolai Kuznetsov and biotechnology specialist Youssef Khesuani.

Nikolai Kuznetsov presented the theory of hidden oscillations—a branch of nonlinear dynamics that allows for the detection of hidden threats in complex engineering systems. Unlike classical oscillations, hidden attractors do not manifest near equilibrium points, making them particularly dangerous. A system can maintain apparent stability for years until a random impact triggers a catastrophic failure.

"Hidden oscillations are not an abstract concept, but a real engineering problem," noted Professor Kuznetsov. "We've learned to detect them before they lead to accidents. Our theory helps prevent power system failures and improves flight safety."

The theory received practical confirmation during the analysis of the accident at the Sayano-Shushenskaya Hydroelectric Power Plant. The methods are already being used in projects with RusHydro and the Elektropribor Central Research Institute, demonstrating that fundamental mathematics is becoming a key tool for ensuring the safety of complex technical systems.

Yusef Khesuani discussed modern advances in 3D bioprinting—a technology for layer-by-layer fabrication of tissue constructs based on digital models. He focused on practical aspects, such as the need for careful selection of printing conditions and subsequent growth of the constructs in bioreactors.

The uniqueness of our collagen solutions lies in their ability to work with cells without neutralizing acidity and their high biocompatibility after implantation, the researcher explained.

The technology is already demonstrating successful use cases, from eardrum repair to the creation of custom-made ear implants. Its future lies in the development of invasive methods that allow printing directly into the damaged area.

Both speakers noted the special role of the Polytechnic University as an integrator of science and practice.

"This is a unique platform where fundamental theory meets real-world challenges," concluded Nikolai Kuznetsov. "It's here that high-tech solutions in demand by the real economy are developed."

Yusef Khesuani added: "Young researchers from the Polytechnic University are renowned for their work, ranging from the creation of new materials to medical diagnostic systems. Seeing such motivated scientists among the audience and exchanging ideas with them creates a unique creative atmosphere."

The Polytechnic's stand confirmed the university's status as a center for interdisciplinary scientific collaborations and the creation of technologies that define the country's technological sovereignty.

The participation of Polytechnic University leadership in the Congress of Young Scientists demonstrated the university's active role in shaping the country's scientific and technological policy and its readiness to implement ambitious projects in partnership with leading research centers and industrial enterprises.

The Polytechnic University serves as a key link between academic research and the real sector. Polytechnic researchers' research in new materials, energy, and digital technologies is directly applied by Russian enterprises. This strengthens the country's technological sovereignty and competitiveness.

Please note: This information is raw content obtained directly from the source. It represents an accurate account of the source's assertions and does not necessarily reflect the position of MIL-OSI or its clients.

Translation. Region: Russian Federation –

Source: Peter the Great St. Petersburg Polytechnic University –

An important disclaimer is at the bottom of this article.

Scientists from Peter the Great St. Petersburg Polytechnic University have developed a new dosage form with encapsulated antitumor compounds for use in the oral treatment of both primary and metastatic melanoma. The researchers synthesized nanoparticles from biocompatible and biodegradable polymers—gelatin (GNPs) and chitosan (ChNPs)—loaded with the therapeutic compound. Research has shown that the nanoparticles help the compound maintain its integrity while passing through the aggressive environment of the human gastrointestinal tract. This allows for maximum effectiveness in oral targeted cancer therapy. The study results were published in the International Journal of Biological Macromolecules.

According to research, melanoma is one of the most aggressive cancers with high metastatic activity. Metastases are the main cause of death in melanoma patients. Standard chemotherapy protocols typically use cytostatic and cytotoxic drugs to destroy cancer cells. However, this approach also has the side effect of destroying healthy cells. A new, modern method is targeted therapy, which destroys only tumor cells. Currently, more than 150 targeted compounds have been approved for the targeted therapy of various oncological diseases. The use of these drugs offers advantages over traditional chemotherapy, as they reduce toxicity to healthy tissue and minimize side effects. Scientists are developing both new, effective drugs and methods for improving their bioavailability.

Researchers are currently studying the efficacy of targeted small-molecule drugs, such as PARP (poly(ADP-ribose) polymerase) inhibitors, in melanoma treatment. Despite their effectiveness, their use is limited by their pharmacokinetics. The main problem with existing PARP inhibitors is their low oral bioavailability. The acidic environment, enzymes, and other biological barriers of the gastrointestinal tract degrade the drug, requiring high doses and reducing its effectiveness.

Scientists from the Institute of Biomedical Systems and Biotechnology at Peter the Great St. Petersburg Polytechnic University focused on creating an effective dosage form for PARP inhibitors that would allow the compounds to maintain their integrity in the gastrointestinal tract. The researchers synthesized nanocarriers based on biocompatible and biodegradable polymers—gelatin (GNPs) and chitosan (ChNPs). These nanoparticles encapsulated a PARP inhibitor synthesized by the study's authors, based on substituted 2-aminothiophene (2AT) derivatives.

In experiments on mice with a solid melanoma model, oral administration of the compound using the new dosage forms resulted in tumor growth suppression by 88–95% compared to the control group. In a model of metastatic melanoma with lung lesions, the nanoformulations of the drug demonstrated an 82% suppression of metastasis formation, noted Sergey Shipilovskikh, PhD in Chemistry and leading researcher at the Laboratory of Nano- and Microencapsulation of Biologically Active Substances at SPbPU.

Using bioimaging techniques (SPECT and fluorescence imaging), scientists have documented that the nanoparticles, after oral administration, effectively accumulate and remain for a long time in the gastrointestinal tract (stomach, small intestine, and colon). This confirms their ability to overcome gastrointestinal barriers and deliver the drug to its target. Studies including histological analysis of organs and blood biochemistry revealed no serious adverse effects from the new dosage forms. The drugs demonstrated a good safety profile.

"Our study demonstrates that encapsulating a PARP inhibitor in gelatin and chitosan nanoparticles increases its bioavailability and therapeutic efficacy when administered orally. This approach allows for effective treatment of not only the primary tumor but also metastases, which is critical for melanoma treatment," noted Anna Rogova, a research assistant at the Laboratory of Nano- and Microencapsulation of Biologically Active Substances at SPbPU and a postgraduate student in Biophysics.

The developed strategy opens up new prospects for the creation of effective and safe oral drugs for targeted therapy of oncological diseases.

Please note: This information is raw content obtained directly from the source. It represents an accurate account of the source's assertions and does not necessarily reflect the position of MIL-OSI or its clients.

Translation. Region: Russian Federation –

Source: Official website of the State –

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On November 26, as part of the business program of the Congress of Young Scientists, an open meeting of the expert council on international educational and scientific cooperation and integration of the State Duma Committee on Science and Higher Education was held. Vladimir Stroyev, Rector of the State University of Management, addressed the audience with a report on approaches to ensuring food security in the current context.

This year's meeting focused on developing the agro-industrial complex and strengthening our country's food security. Vladimir Stroyev, Rector of the State University of Management, focused on the specifics and challenges of training personnel for Russia's agro-industrial complex (AIC) and the principles by which the university addresses this issue. He also presented the results of the major research project "Ensuring the country's food security through the creation of hardware and software systems and intelligent platform-based digital solutions for the development of full-lifecycle agro-industrial technologies," which is being implemented by the university.

"Without digitalization in the agricultural sector, we're operating in the dark. Average fertilizer doses, guesswork in watering, and losses during storage and logistics all increase production costs and make it unprofitable. Precision farming allows for targeted inputs, saving money. Digital platforms can forecast prices and optimize logistics, further reducing production losses. Furthermore, digital twins of agricultural entities and AI-based forecasting systems allow us to model threats and mitigate them by taking proactive measures. In other words, digitalization is a direct path to reducing costs and increasing margins. Without it, we won't be able to compete in either the international or domestic markets," Vladimir Vitalyevich emphasized.

The interdisciplinary presentations included Maria Mazhorina, Vice-Rector for Strategic and International Development and Head of the Development Program at Kutafin Moscow State Law University (MSAL), Inna Andronova, Dean of the Faculty of Economics at Peoples' Friendship University of Russia (RUDN University), and Oleg Karasev, Deputy Director General of the Directorate for Scientific and Technical Programs. The speakers covered issues of innovation law for ensuring Russia's technological leadership, developing foreign economic cooperation, and measures to support international cooperation in the agricultural sector.

Industry reports on the agricultural and food industries were presented by Elena Simonenko, Head of the Forecasting Department at the Research Institute of Baby Food, a branch of the Federal Research Center of Nutrition and Biotechnology; Andrey Ronzhin, Professor at the Russian Academy of Sciences and Director of the St. Petersburg Federal Research Center of the Russian Academy of Sciences (SPb FRC RAS); Dmitry Pavkin, Head of the Robotics and Digitalization of Animal Husbandry Research Center at the Federal Scientific Agroengineering Center VIM; Ekaterina Zhuravleva, Advisor to the Chairman of the Board of Directors of EFKO Group; Artem Oganov, Professor at Skoltech and Head of the Materials Design Laboratory; and Irina Karelina, Vice President of the National Research University Higher School of Economics (HSE).

The results of the open meeting were summarized by Ksenia Trinchenko, Director of the Department of International Cooperation at the Russian Ministry of Education and Science; Alexander Vedekhin, Deputy Director of the Department of State Youth Policy and Educational Activities at the Russian Ministry of Education and Science; Ilya Orsik, Deputy Head of the Department of Agricultural, Food, and Road Construction Machinery at the Russian Ministry of Industry and Trade; and Pavel Shevtsov, Deputy Head of Rossotrudnichestvo. The speakers emphasized the high importance of the topics raised during the meeting, noting the need for an interdisciplinary and comprehensive approach to addressing food security in Russia and training personnel for the agricultural sector.

At the conclusion of the event, Vladimir Sipyagin, First Deputy Chairman of the State Duma Committee on Science and Higher Education, proposed including in the list of initiatives for the Decade of Science and Technology a proposal to create a federal project, "Science Unites the World," to strengthen international scientific cooperation and address the global challenges of the 21st century. The key areas of the initiative are the creation of international laboratories for young scientists, the organization of educational programs, the implementation of technology projects, the exchange of scientists and students, and the holding of international events.

Subscribe to the "Our GUU" Telegram channel. Publication date: November 27, 2025.

Please note: This information is raw content obtained directly from the source. It represents an accurate account of the source's assertions and does not necessarily reflect the position of MIL-OSI or its clients.

Translation. Region: Russian Federation –

Source: Peter the Great St. Petersburg Polytechnic University –

An important disclaimer is at the bottom of this article.

The intellectual game "Megapolisi" was held at the "Polytech Tower" space of Peter the Great St. Petersburg Polytechnic University. Organized by the Trade Union Bureau of the Civil Engineering Institute, the event was a shining example of how professional knowledge and creativity can combine in a dynamic, educational, and modern format.

Students from the Institute of Civil Engineering and Guest Speakers, as well as guests from other Polytechnic institutes, participated in the event. On behalf of the Institute of Civil Engineering, the event was organized by Trade Union Bureau activists and student academic group leaders.

The game program included questions on the construction industry: architecture, building materials, technologies, engineering solutions, and modern tools. Intellectual rounds allowed participants to test their knowledge, review their course material, and broaden their horizons.

The event culminated in a creative round, where teams had to create their own concept for the megacity of the future. Participants presented original city designs, focusing on infrastructure, environmental friendliness, technological advancement, and convenience for residents.

At the end of the event, participants discussed the proposed concepts and shared their opinions on the game.

I really enjoyed it! Especially the fact that we didn't try to compete with each other, but actually answered the questions together. The organization was excellent: everything went exactly according to schedule, without any delays. We had a great time and laughed a lot! — noted Darina Filimonova, first-year leader at the Civil Engineering Institute.

Please note: This information is raw content obtained directly from the source. It represents an accurate account of the source's assertions and does not necessarily reflect the position of MIL-OSI or its clients.