Translation. Region: Russian Federation –
Source: Novosibirsk State University –
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The 12th OpenBio Biotechnology Forum, held in late September, brought together 992 in-person and 4,411 online participants from 13 countries in the science city of Koltsovo. Representatives from businesses, scientific institutes, and research centers met at the forum to discuss the development of biotechnology, biopharmaceuticals, and related fields.
One of the participants was Sergey Dementyev, a second-year master's student at the NSU Physics Department. Sergey presented an oral presentation, "Functional Properties of Spin Trapping Agents for Enhanced Detection of Singlet Oxygen in Photodynamic Therapy Applications," in the biophysics section and won first place among young scientists under 35. As a prize, he received a certificate for training in "Machine Learning in Biology and Bioinformatics."
"I'm interested in the forum as a platform for science and business to build practical partnerships. I'm particularly interested in collaborating with pharmaceutical companies on joint drug testing projects," Sergey said.
The research presented by Sergey was conducted in collaboration with the Laboratory of Nitrogen Compounds at the Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences. The work focuses on the discovery and study of new spin traps—compounds that enable more accurate detection of singlet oxygen in biological systems.
"Our proposed trap demonstrated the best performance and proved to be the most promising for these applications. This result is important for studying the in vivo antitumor properties of photosensitizers used in photodynamic cancer therapy," explains Sergey.
Photodynamic therapy is a non-invasive cancer treatment method already widely used in clinical practice. The search for new photosensitizers is a key step in improving its effectiveness.
“The compound we proposed makes it possible, for the first time, to conduct more in-depth studies of these drugs under physiological conditions—both in vitro and in vivo—compared to the standard testing procedure on mice,” the researcher notes.
Work on the project was carried out in the Electron Paramagnetic Resonance Spectroscopy Laboratory of the International Tomography Center of the Siberian Branch of the Russian Academy of Sciences under the supervision of Doctor of Physical and Mathematical Sciences Olesya Anatolyevna Krumkacheva.
"The most challenging and, at the same time, interesting part was mastering and combining several experimental techniques necessary for the project's implementation. In the future, we plan to use the developed traps to study new promising photosensitizers synthesized by our colleagues," added Sergey.
The material was prepared by: Yulia Dankova, NSU press service
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