Category: Наука и инновации/

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Source: Peter the Great St. Petersburg Polytechnic University –

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The Avangard Technological Lyceum in Omsk hosted the "Engineering Education Day" festival, bringing together leading national and regional universities, industrial enterprises, and organizations developing engineering and digital technologies. Among the participants was Peter the Great St. Petersburg Polytechnic University. Vladimir Voronov, an engineer at the Industrial Stream Data Processing Systems Laboratory of the Advanced Engineering School "Digital Engineering" at SPbPU, represented the Polytechnic University.

Guests at the event at the Avangard Technology Lyceum saw how MKAR is helping develop competencies in the field of unmanned systems.

The PSPOD laboratory showcased its development—the compact, wheeled, autonomous robot MKAR 3.1. The exhibit generated great interest among schoolchildren, teachers, and parents. Festival guests learned about the robot's capabilities and how it can be used to develop engineering and digital competencies in schoolchildren and students.

MKAR 3.1 is a new version of the educational and methodological toolkit for teaching robotics, unmanned systems, and programming. The robot is built on the ROS2 operating system and features omnidirectional wheels, modern sensors, and a modular design that allows for customization of its functionality to meet specific learning objectives. It also comes with a virtual simulator, enabling training even without access to a physical model.

Omsk boasts a modern educational center, the Avangard Lyceum, which educates talented and motivated students with a genuine interest in new engineering solutions and unmanned technologies. At the event, we saw keen interest from both students and their parents. Many carefully studied the design and functionality of the MKAR. Events like these are undoubtedly important for promoting engineering education and fostering a deeper understanding of modern unmanned systems among a wider audience, noted Vladimir Voronov.

The MKAR exhibit was part of the festival's extensive educational program, which included lectures and master classes from leading engineers, researchers, and industry representatives. The event was also attended by representatives of Omsk State Technical University, Omsk State Agrarian University, the Quantorium children's technology park, the Omsk Oil Refinery, and other industry representatives.

The Engineering Education Day festival is an excellent platform for showcasing cutting-edge engineering practices and strengthening ties between educational institutions, the scientific community, and industry. The participation of SPbPU and its laboratories in such events contributes to the strategic goal of building a continuous system of engineering education, from school to successful careers in industry.

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The 27th All-Russian Seminar with international participation on jet, separated, and unsteady flows of liquids, gases, and plasma was held in St. Petersburg at the D. F. Ustinov Belarusian State Technical University "VOENMEKH."

The seminar was attended by Nikolai Ivanov, Director of the Institute of Physics and Mechanics; Nikolai Bykov, Professor of the Physics Department; Evgeny Smirnov, Professor of the Higher School of Applied Mathematics and Computational Physics; and Mikhail Strelets, Head of the Computational Hydroaeroacoustics and Turbulence Laboratory. Nikolai Ivanov co-chaired the "Flows in Nozzles and Channels, Interior Ballistics" section, and Nikolai Bykov co-chaired the "Jet Technologies, Environmental Issues, and Safety Equipment" section.

At the seminar, participants discussed new results from theoretical, numerical, and experimental research in the fields of fluid, gas, and plasma mechanics, as well as their practical applications in aviation and space technology, energy, ecology, and a number of other fields. Presentations were given by scientists, engineers, and specialists from educational, design, scientific, and industrial organizations in Russia and the Republic of Belarus.

Professor Evgeny Smirnov presented a keynote address at the "Unsteady Flows, Aero- and Hydroacoustics" section, titled "The Structure of a Turbulent Jet Generated by a Ring System of Fluid Oscillators." Senior Lecturer Anna Podmarkova and graduate student Vladislav Adiatullin also presented their papers at the same session.

Nikolai Bykov presented a paper entitled "Rarefied Gas Jets: Astrophysical Applications and Vacuum Technologies" at the "Dynamics of Rarefied Gases" section.

Other faculty members, graduate students, and undergraduate students from the Polytechnic University also presented their papers at the seminar. The presentations by the Polytechnic University students demonstrated the high level of SPbPU's scientific school.

You can find out more about the past seminar on the website of the Physics and Mechanical Institute.

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The 12th International Technological Development Forum, Technoprom-2025, was held in Novosibirsk. The event was held as part of Russian Science and Technology Week. The theme of Technoprom-2025 was "Science, Human Resources, Industry: Key Components of Technological Leadership." The event's focus was "Technology as a Factor in Regional Development." The goal of the forum was to discuss a range of measures to ensure technological breakthroughs.

Over the course of three days, experts discussed key issues related to the accelerated implementation of scientific research results in the economy, staffing of priority sectors, increased investment in science by the government and business, and the involvement of talented young people in scientific, technological, and innovative activities.

The forum's business program included seven industry tracks dedicated to unmanned aerial systems, nuclear and energy technologies, new materials and chemistry, production and automation equipment (including robotics and instrumentation), new health-preserving technologies, technological support for food security, environmental well-being, and climate.

The program also included four thematic tracks focused on discussions in the areas of intellectual property, science and technology governance systems, key areas and current results of the Decade of Science and Technology, and regional participation in national projects to ensure technological leadership.

Each track featured plenary sessions, roundtables, strategic sessions, and business meetings. The forum was complemented by 11 satellite events, including the 19th Siberian Venture Fair, the 2nd Russia-Africa Forum, the 1st Eurasian Export Forum, the 5th National Technology Transfer Forum, and other significant events.

The organizers of Technoprom-2025 were the Government of the Russian Federation, the Government of the Novosibirsk Region, the Siberian Branch of the Russian Academy of Sciences, and Novosibirsk State University.

As per tradition, universities from the Priority 2030 program and the Advanced Engineering Schools project participated in the largest technology event. During these days, they presented cutting-edge developments and, together with industrial partners, discussed key issues in the development of engineering education at the Sociocenter booth of the Federal State Autonomous Institution. The team from the Advanced Engineering School of Peter the Great St. Petersburg Polytechnic University, "Digital Engineering," participated in the Technoprom-2025 forum for the ninth time, including presenting innovative developments and key educational approaches at the Sociocenter booth.

Alexey Borovkov, chief designer of the key scientific and technological development area at SPbPU, "System Digital Engineering," and director of the SPbPU PIS, was one of the key speakers at the Sociocenter, a Federal State Autonomous Institutional Organization (FSBI) event dedicated to discussing current issues and development paths for engineering education in Russia, as well as the role of effective cooperation between universities and industrial partners in this process.

Alexey Borovkov took part in the following events:

Design session "Development strategies for engineering universities"; discussion "The future of engineering education: key trends"; discussion "Project office versus university: conflict of initiatives for the development of current activities".

The design session "Development Strategies for Engineering Universities" examined promising models for developing engineering education in the context of the digital transformation of the economy. Participants discussed the need to integrate development strategies into university development programs, as well as approaches to developing and modernizing educational programs in light of new goals.

According to Alexey Ivanovich, a key aspect of university activity is collaboration with industrial partners and participation in national technological leadership projects. The speaker emphasized that universities need to not only participate in all key scientific and technological areas, but also select those in which the university has competitive competencies and scientific and technological groundwork.

"I'm deeply convinced that what's currently underway is a competition between the scientific and technological advances of universities and research centers. We must be able to adapt these advances quickly enough to meet the current frontier engineering challenges of industry," concluded Alexey Borovkov.

The discussion "The Future of Engineering Education: Key Trends" identified key areas for the development of engineering education, including the need to strengthen practical training and develop competencies in systems engineering and digital modeling.

During the discussion "Project Office vs. University: Conflict of Initiatives for the Development of Current Activities," participants discussed current issues of coordinating the project activities of universities and project offices, and also noted the main forms of balance between current activities and strategic development initiatives.

Alexey Borovkov's speeches and participation in events organized by the Federal State Autonomous Institution "Sociocenter" highlight the significant role of SPbPU in shaping the strategy for the development of engineering education in Russia and its active position on issues of integrating science, education, and industry.

The Federal State Autonomous Institution "Sociocenter" booth featured technological solutions from the SPbPU PISh in the field of thermoplastic polymer composite materials and additive technologies:

Demonstrator of automated lay-up technology for thermoplastic unidirectional prepregs; demonstrator of induction welding technology for thermoplastic polymer composite materials; demonstrator of overprinting technology.

A demonstrator of automated thermoplastic unidirectional prepreg layup technology presented to exhibition participants the possibilities of creating multilayer composite structures with a specified reinforcement structure, including products with complex geometries and unlimited sizes. This is relevant for aircraft manufacturing, including unmanned aerial vehicles and aircraft, engine manufacturing, rocket and space technology, shipbuilding, and transportation.

The TPKM induction welding technology demonstrator allowed experts to evaluate a method for welding carbon fiber reinforced plastics with matrices made of any thermoplastic polymers, with a total weld thickness of up to 7.5 mm and achieving strength characteristics twice as good as those achieved with specialized adhesives.

An overprinting technology demonstrator presented a method for producing three-layer composite panels that combines automated skin layup and additive manufacturing of a variable-stiffness honeycomb core. Overprinting technology allows these components to be integrated into a single structure, providing increased impact resistance, reduced weight while maintaining strength, the ability to locally reinforce structures, and a reduction in the number of manufacturing steps.

Alexey Borovkov discussed the main projects and initiatives of the SPbPU Advanced Engineering School "Digital Engineering" in the field of composite materials and additive manufacturing, as well as the exhibits on display at the exhibition, at the roundtable "Advanced Materials and Digital Materials Science." Experts discussed the key challenges and prospects for implementing new materials in various industries. The discussion focused on the goals, objectives, and progress of Subdirection 4 of the VTN Cultural Center "Technologies of New Materials and Substances": "Advanced Materials and Digital Materials Science," as well as the objectives and best practices of digital materials science.

Digital modeling allows us to predict the properties of materials, improve their performance, manage them effectively, and significantly reduce the time required to develop new solutions to achieve technological leadership, noted Alexey Borovkov, citing examples of successful projects in aircraft manufacturing, including unmanned aerial vehicles (UAVs), and in nuclear energy.

Engineer at the Polymer Composite Materials Laboratory at SPbPU's PISh, PISh Class of 2025 Master's program "Mechanics of Polymer and Composite Materials" Natalia Grozova was a speaker at the pitch session "Pish Graduates: Student Experience and Cutting-Edge Developments." She told about the specifics of training at the Advanced Engineering School of SPbPU "Digital Engineering" and the participation of graduate students in the development of science-intensive projects in the field of TBM with industrial partners based on Laboratory of Polymer Composite Materials PISH SPbPU.

Alexey Borovkov introduced the participants round table "Collective Use Centers and Unique Scientific Facilities: Prospects and Challenges" The capabilities of another advanced SPbPU infrastructure facility—the Polytechnic Supercomputer Center—were discussed. The speaker highlighted the center's unique digital architecture, which is used to solve high-tech problems for research teams from SPbPU departments, researchers from third-party institutes and organizations of the Russian Ministry of Education and Science, the Russian Academy of Sciences, other scientific and educational organizations, industrial enterprises, individual entrepreneurs, and other individuals conducting R&D.

The Polytechnic Supercomputer Center boasts high-performance computing systems with a total peak performance of over 4.5 peta-flops for the efficient solution of various resource-intensive scientific and technological problems, placing it at the forefront of supercomputer centers at universities within the Russian Ministry of Education and Science.

To solve today's frontier engineering challenges in industry and to carry out breakthrough R&D, supercomputer infrastructure must be complemented by a developed cyber infrastructure. The digital platform for the development and application of digital twins CML-Bench® [1, 2] is one of the key elements of the cyberinfrastructure of the Advanced Engineering School of SPbPU "Digital Engineering." The digital platform allows PESH engineers to store and use data, mathematical and computer models [1 , 2], undergone procedures verification Andvalidation, the results of numerous digital (virtual) tests, including using digital (virtual) test benches Andpolygons, forming a unique scientific and technological foundation in the field of systems digital engineering. Currently, the CML-Bench® Digital Platform hosts over 373,000 digital and design solutions. The synergy of supercomputer and cyber infrastructure creates the potential for over 100 R&D projects annually. To solve knowledge-intensive multidisciplinary problems, over 100 digital (virtual) tests are conducted every day, concluded Alexey Ivanovich.

The experience of SPbPU Advanced School of Engineering (ASE) engineers in integrating artificial intelligence technologies into the CML-Bench® Digital Platform for the Development and Application of Digital Twins was presented at a roundtable discussion entitled "ASE Practices in the Use of Artificial Intelligence Technologies." Alexey Borovkov presented a paper entitled "AI Assistant (Chatbot) in Systems Digital Engineering as a Tool for Systematizing Knowledge and Training Engineers at the ASE "Digital Engineering." At the event, representatives of the Advanced Schools of Engineering shared best practices in the use of artificial intelligence in education, science, and industry.

In addition, Alexey Borovkov took an active part in the panel discussion "Business Investments in Science: Problems and Prospects," organized by the Russian Union of Industrialists and Entrepreneurs (RSPP). The discussion focused on the conditions for business investment in scientific projects, research groups, and scientific and technological infrastructure, identifying and formulating the specifics of technology localization for the purpose of achieving technological leadership, and developing, based on the results of the expert session, proposals for amendments to current legislation that would facilitate the development of measures for expansion.

One possible form of "investing in science" is investing in the development of qualified partnerships. The development and implementation of a qualified partnership model involves regular collaboration between a qualified client and a qualified contractor, ideally based on roadmaps. Such roadmaps enable the establishment of long-term and planned collaborations with leading state corporations such as Rosatom, Rostec, Roscosmos, Gazprom Neft, and others, which act as qualified clients. Through such collaboration, university departments focused on solving frontier engineering problems and performing commissioned R&D, primarily the Advanced Engineering Schools, which have progressed from fundamental research to applied R&D and innovative developments, accumulate knowledge and build a significant scientific and technological foundation, enabling them to qualify as qualified contractors, noted Alexey Ivanovich.

The Technoprom-2025 Forum became an innovative platform where representatives from regions, enterprises, scientific and educational organizations, development institutions, and federal executive bodies, along with colleagues from friendly countries, were able to discuss issues related to the country's scientific and technological development and build interregional and international cooperation chains to achieve technological leadership using specific projects, case studies, and technological developments.

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Scientists from Peter the Great St. Petersburg Polytechnic University have created a unified database of chalcogenide glasses, which contains more than 20,000 records of their compositions and properties. The database is based on information published in scientific studies over the past 50 years, and includes most of the existing experimental results of studying the characteristics of chalcogenide glassy materials. Database chalcogenide glasses is patented and registered by the Federal Service for Intellectual Property (Rospatent). To work with the database, the Polytechnics developed a web interface that allows sorting, exporting and analyzing data by composition and properties. Thanks to this, new opportunities are opening up for the accelerated design of promising chalcogenide glasses – key materials for modern infrared optics, thermal imagers and night vision systems.

Chalcogenide glasses are amorphous inorganic materials in which oxygen atoms are replaced by sulfur, selenium or tellurium atoms. Chalcogenide glasses have attracted attention since their discovery due to their unique properties: due to the absence of oxygen in the structure, they have wide transparency in the infrared range, a high refractive index and a low softening point. The growth of practical interest in these materials in the last five years is associated with the development of thermal imaging systems and a more than threefold increase in the price of single-crystal germanium, the main material for the infrared spectral region up to 14 μm. Due to the great fragmentation and lack of systematization of published data, as well as the lack of a system for displaying the characteristics of glass compositions, the process of developing new compositions with the required set of properties has become more complex. Traditionally, it is based on the analysis of phase diagrams and the construction of local regression models.

To solve this problem, an interdisciplinary group of scientists from the Scientific and Educational Center "Nanotechnology and Coatings" of the Institute of Mechanical Engineering, Materials and Transport and the Higher School of Software Engineering of SPbPU carried out large-scale work to create a unified database. Using large language models (LLM – Large Language Model), scientists aggregated and structured information from more than 1000 scientific publications. In addition to the database itself, using artificial intelligence methods, models were developed to predict the properties of previously unknown glass compositions.

The main result of the work was not just a database, but an entire analytical platform. For the convenience of researchers, a specialized web interface has been developed that allows for prompt data analysis, comparison of results, and export of search results. To simulate the characteristics of glass before the stage of expensive laboratory synthesis, a model for predicting key glass parameters (density, softening temperature, refractive index) was developed based on machine learning models and neural networks. The proposed approach significantly reduces the time spent on developing promising compositions at the initial stage of research. In the future, it is planned to expand the scope of application of the predicted glass parameters, – said the project manager, PhD in Physics and Mathematics Victor Klinkov.

The software package can serve as a basis for the emergence of a new approach to the design of optical systems. The platform lays the foundation for a fundamentally different methodology: now it is possible to design "from the opposite" – from the characteristics required by the system to the targeted synthesis of material with the necessary parameter values. An important aspect of the project is its general availability. The platform creates a single field for scientific work, allowing both novice scientists and experienced specialists to quickly analyze their results in the context of global research practice and plan new projects.

The practical significance of the work lies in expanding the boundaries of understanding the nature of the glassy state using AI tools and in creating prerequisites for implementing these results in industrial optics design systems. Today, there are no direct analogues of the developed platform in Russia.

The work was carried out within the framework of the Blue Sky Research Digital Labs Campus project with the support of the St. Petersburg Foundation for the Support of Innovations and Youth Initiatives. Now scientists are improving the algorithmic support and expanding the functionality of the platform for the international scientific community.

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Head of the Department of Higher Mathematics at the Institute of Physics and Mathematics, Professor Ilya Sysoev, received a grant from the Idea Scientific Center to open a postgraduate position in neuroscience, becoming winner of the 2025 competition.

The competition was held for the fifth time (in 2024, the project of Marina Sysoeva, professor of the Physics Department at the Institute of Physics and Mathematics, won).

This year, 15 projects out of 37 applications received support based on the results of the competition. The research topic proposed by I. V. Sysoev "Modeling of short-term memory processes as dynamic modes in hippocampal neuron networks" involves an interdisciplinary approach that combines mathematical modeling, methods of nonlinear dynamics, processing of electrophysiological signals and computational methods. In order to conduct research in the field of fundamental neurosciences, the research laboratory "Fundamental cognitive research" was created at the Institute of Physics and Mathematics of SPbPU in 2025, where two projects supported by grants from the Russian Science Foundation are already being carried out. The grant from the scientific center "Idea" is intended to pay a postgraduate student an additional stipend of 80 thousand rubles per month for the entire period of study.

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Scientists from the Civil Engineering Institute of Peter the Great St. Petersburg Polytechnic University are conducting research aimed at identifying and systematizing natural and climatic data of the Arctic zone of Russia.

The project is being implemented under the scientific supervision of Yuri Lazarev, professor at the Higher School of Industrial, Civil and Road Construction. The head of the research group is Liliya Talipova, senior lecturer at the Institute of Civil Engineering and Road Construction. Yegor Grebenyuk, engineer at the Higher School of Industrial, Civil and Road Construction, and Evgenia Morozova, assistant, are also working on the project.

At the current stage of research, the team has developed a database that includes geological, climatic, ecological and environmental data of the Arctic region of Russia. In the course of implementing the database, the attributive characteristics, requirements for the structure and storage of data are being clarified. At the moment, a computer program is being developed that allows for automatic updating of the developed database.

The result of the project will be a GIS (geographical information system) platform that designers will be able to use at the initial stages of designing both linear and area objects in permafrost conditions. The planned release date for the platform is March 2026.

The development of the platform allows for the collection and processing of data, modeling of processes, and analysis at the pre-project stage. The developed database made it possible to systematize spatial, geological and geotechnical, climatic, environmental and nature conservation data, noted Liliya Talipova.

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A research team led by SPbPU professor Vladimir Ivanov, in partnership with neurosurgeons from a specialized hospital in Chennai (India), has successfully tested an improved version of a surgical navigation system based on artificial intelligence and augmented reality. The development allows detailed 3D holograms of brain structures integrated with MRI data to be projected onto the surgical field in real time, which increases the accuracy of interventions and reduces intraoperative risks.

Surgical navigation is the gold standard in modern neurosurgery. However, traditional systems have limitations, requiring the surgeon to constantly shift his gaze from the surgical field to a separate monitor. Augmented reality (AR) and artificial intelligence (AI) technologies are designed to solve this problem by integrating virtual 3D models of anatomical structures directly into the surgeon’s field of view.

One of such promising developments is the Medgital Vision software and hardware complex, created by the research group of Professor Vladimir Ivanov from the Higher School of Theoretical Mechanics and Mathematical Physics of SPbPU.

The Medgital Vision system is a complex that combines algorithms of computer vision, machine learning and augmented reality.

3D reconstruction. Based on MRI/CT data, AI algorithms create highly accurate 3D models of the surgical area, in particular, complex brain structures. Holographic projection. The model in the form of an interactive hologram is projected directly onto the surgical field through an AR headset or a specialized display, providing the surgeon with “X-ray” vision. Intraoperative navigation. The system tracks the position of surgical instruments in real time and combines them with a virtual hologram, ensuring the highest navigation accuracy.

The updated version of the system was tested by the leading developer Ildar Mamaev at a specialized hospital. At the request of Indian colleagues, the AI algorithms were modified for even more detailed visualization of specific areas of the brain. The very first operation performed using the updated system confirmed its clinical effectiveness and stable operation in the conditions of a real surgical process.

The success in India continues a series of international adoptions of the technology.

2023 — the first operations using the system were performed in medical centers in Turkey and Belarus. 2024 — the development received top awards at prestigious international competitions HICOOL (China) and ITECH (China). 2025-2026 — it is planned to implement the system in clinics in Mexico and Ecuador, as well as to open a full-fledged representative office in India.

The head of the Committee for Industrial Policy, Innovation and Trade of St. Petersburg, Alexander Sitov, noted: St. Petersburg has enormous potential in creating artificial intelligence technologies. We are among the leaders in the country in the field of AI development. The city helps developers determine the maturity level of their technologies and promote them to international markets, which is clearly demonstrated by the success of the Medgital Vision project.

Professor Vladimir Ivanov emphasized: Entering the international arena is not only a commercial task for us, but also an important stage in validating the technology. Each new implementation in the world's leading clinic provides invaluable data for further improvement of artificial intelligence algorithms and increasing the accuracy of the system.

Successful testing of the Medgital Vision system in India confirms its competitiveness in the global medical equipment market. The development of St. Petersburg scientists makes a significant contribution to the development of digital surgery, allowing to increase safety and reduce the invasiveness of complex neurosurgical operations. Further international expansion and collection of clinical data will contribute to the evolution of the system towards full automation of surgical planning.

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Researchers from the Institute of Biomedical Systems and Biotechnology of Peter the Great St. Petersburg Polytechnic University (SPbPU) have proposed a new strategy to combat Alzheimer's disease. The results of their work were published in the prestigious international journal The Journal of Neuroscience.

Alzheimer's disease remains one of the most common and devastating neurodegenerative diseases in the world.data According to the World Health Organization, 57 million people worldwide suffer from dementia, with 60–70% of cases suffering from its most common form, Alzheimer's disease. As scientists note, this disease is caused by harmful substances accumulating in the brain: β-amyloid, which forms plaques, and tau protein, which curls into balls. This interferes with the normal functioning of nerve cells, disrupts the connection between them, and gradually leads to deterioration of memory and thinking. Modern therapeutic approaches are mainly associated with attempts to remove these plaques from the brain, but in practice they do not show high efficiency.

SPbPU scientists focused on another fundamental problem accompanying Alzheimer's disease — the imbalance of calcium ions inside neurons. As the authors of the study explain, calcium plays the role of a key signaling element in nerve cells. Normally, its concentration inside the cell is strictly controlled. In Alzheimer's disease, toxic β-amyloid disrupts this regulation, causing a massive and uncontrolled flow of calcium into neurons. Calcium overload leads to cell hyperactivity, disruption of neural connections and, ultimately, to their death, which is manifested by loss of memory and cognitive functions. Instead of blocking calcium channels (an approach that often leads to serious side effects), scientists proposed helping the cell cope with the problem itself. Their attention was drawn to the intracellular SERCA pump, which is responsible for pumping excess calcium into special storage facilities. The hypothesis was that enhancing the work of this pump could protect neurons from calcium stress.

In the first stage, the researchers tested six substances that could potentially activate the SERCA pump. Using cell models with a fluorescent calcium sensor, they identified the most effective compound, NDC-9009. Not only did it normalize calcium levels in neurons better than others, but it also protected them from the damaging effects of β-amyloid, preserving the integrity of dendritic spines, structures that are critical for memory formation. Having confirmed its effectiveness in cell models, the scientists moved on to testing on mice with an Alzheimer's disease model. To monitor brain function in real time, they used cutting-edge technology — miniscopeIt is a miniature microscope that is attached to the head of a freely moving rodent and allows the activity of hundreds of neurons to be recorded simultaneously, for example in the hippocampus, the brain's memory center.

Mice with Alzheimer's disease showed chaotic and excessive neuronal activity. After a course of intraperitoneal administration of NDC-9009, the activity of their neural networks normalized, becoming similar to that of healthy animals. More importantly, this restoration of brain function was accompanied by a clear improvement in memory and learning ability in behavioral tests. The analysis of data obtained from the miniscope was carried out using software we developed earlier NeuroactivityToolkit, — explained Evgeny Gerasimov, a research engineer at the Laboratory of Molecular Neurodegeneration and the Laboratory of Biomedical Image and Data Analysis at SPbPU.

These results indicate that SERCA pump modulators, and NDC-9009 in particular, offer a promising new avenue for the treatment of Alzheimer's disease. This approach targets a fundamental mechanism of cell death, calcium imbalance, and may have a more favorable safety profile than existing therapies.

The work was completed by a team of authors: Evgeny Gerasimov, Anastasia Rakovskaya, Ekaterina Pchitskaya, Olga Vlasova, Dal Russell and Ilya Bezprozvanny within the framework of project No. 075-15-2024-548 in priority areas of scientific and technological development of the Ministry of Science and Higher Education of the Russian Federation.

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The key event in the 2025 schedule of off-site events is the visit of the NTR team to the country's leading technical university, which allowed them to discuss the prospects for the development of engineering science, determine priorities and highlight key challenges in the city's technological development. The event took place in the Kapitsa conference hall of the Technopolis Polytech Research Building. The participants were welcomed by the Vice-Governor of St. Petersburg Vladimir Knyaginin and the First Vice-Rector of SPbPU Vitaly Sergeev.

"The Government of St. Petersburg sees its key role in being a catalyst and a bridge between science and business," Vladimir Knyaginin addressed the meeting participants. "We create conditions for their effective interaction: we form a common technological agenda, support high-tech projects and help bring university developments to the industrial level. Such coordination allows us not only to generate breakthrough ideas, but also to implement them in real production, creating new products and strengthening our technological sovereignty."

The visit of the NTR team to the university confirms the importance and relevance of scientific and technological developments of our scientists. The dialogue in which the Polytechnic University acts as an integration platform is important for effective interaction between academic science, government and the real sector of the economy. We are confident that such synergy is a key factor in strengthening the scientific and technological sovereignty and competitiveness of the region, – emphasized the First Vice-Rector of SPbPU Vitaly Sergeev.

The heads of the university's flagship research departments presented the achievements of scientific and technological development in the field of engineering sciences.

Chief designer for the key scientific and technological development area of SPbPU "System Digital Engineering", director of the Advanced Engineering School of SPbPU "Digital Engineering" Alexey Borovkov presented the ecosystem of technological development of SPbPU, combining scientific, educational and engineering competencies to solve multidisciplinary problems for more than 10 high-tech industries: aircraft and UAV manufacturing, engine manufacturing, nuclear and oil and gas engineering, medical engineering, automotive manufacturing, railway transport, etc.

The digital platform for the development and application of digital twins CML-Bench® is the main tool for conducting breakthrough research, ensuring the capitalization of knowledge and competencies. The CML-Bench® Digital Platform currently presents more than 373 thousand digital and design solutions formed based on the results of work with leading industrial enterprises of Russia, – noted Alexey Borovkov.

Dmitry Bogdanov, Director of the Gazpromneft-Polytech Scientific and Educational Center, highlighted the center's key projects aimed at digitalizing the oil and gas industry and presented the results of developing a software package for the automated selection of optimal drilling targets.

"Our AI algorithm analyzes an array of geological and field data: residual oil-saturated thicknesses, reservoir pressure maps, the position of the flooding front," the speaker said. "This allows us to find promising zones and automatically place well trajectories in them with maximum economic effect, minimizing the routine work of experts."

He also demonstrated the results of mathematical modeling of hydraulic fracturing (HF) using a liquid foamed with gas. He emphasized that the 2D and 3D models developed by the center can significantly increase the sand-bearing capacity of the liquid and, as a result, increase the conductivity of the created cracks, which is critically important for efficient production from low-permeability reservoirs.

The delegation visited the laboratories and production sites of the university, where the director of the Scientific and Educational Center "Mechanical Engineering Technologies and Materials" Pavel Novikov gave a presentation on the main areas of research activities in the field of additive and laser technologies.

In his speech, Pavel Novikov focused on the triad of technological leadership: materials, technologies and production. He spoke about the development and production of new materials, in particular, high-entropy alloys and ceramics for rock-cutting tools, as well as intelligent materials with programmable properties.

The key element of the presentation was the demonstration of the domestic high-temperature layer-by-layer laser synthesis installation “VPLS Mercury”, developed jointly with ZAO Biograd (3DLam).

This installation, with a working area heated to 1300°C and a multi-laser system, allows us to manufacture gas turbine parts from heat-resistant alloys with characteristics superior to foreign analogues, Novikov said.

The guests were shown printed samples of a feather segment and a working blade.

Particular attention was paid to technologies for repair and restoration of critical components of power engineering. Using the example of repairing blades of gas turbine engines (GTE) Man Turbo and Mars100, it was clearly shown how laser cladding allows for the restoration of expensive parts made of alloys such as Mar-M-309, Inconel 792 and Mar-M 247, significantly extending their life cycle and reducing replacement costs.

Promising developments were also presented.

WAAM technology for printing large-sized parts, such as impellers and wheel rims, with high productivity (up to 6 kg/hour for titanium) and significant material savings. Creation of functionally graded and multimaterial parts, such as actuators made of NiTi (nitinol) alloy for the aerospace industry and combustion chambers for liquid rocket engines made of a combination of 316L and FeNi36 steels. Development of smart materials and structures, including antennas with specified properties and optimized cellular structures for medical implants.

"Our developments are not just scientific projects, they are ready-made solutions for industry," Pavel Novikov noted. "We not only create new materials and technologies, but also manufacture our own equipment: centers for direct laser growth and robotic complexes for electric arc growth, which allows us to offer customers a full cycle – from the idea to the finished product."

In conclusion, he noted that the future of additive manufacturing lies in the area of process intelligence using artificial intelligence, hybridization of methods and convergence of materials, which opens up new opportunities for critical industries such as aerospace, energy and medicine.

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

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Translation. Region: Russian Federal

Source: Peter the Great St. Petersburg Polytechnic University –

An important disclaimer is at the bottom of this article.

Valeria Rekina, a graduate of the Master's program at the Civil Engineering Institute in the Design program (profile Design in Digital Marketing) from Severodvinsk, created a prototype of a mobile version of a website for multidisciplinary medical clinics. Her development won thegrant competition of the Committee on Science and Higher Education St. Petersburg and interested specialists.

As Valeria notes, the relevance of the project is made up of a combination of three aspects.

Federal project "Creation of a single digital circuit in healthcare based on the unified state information system (EGISZ)". Research in the field of medical marketing, which notes the trend of increasing consumer demand for paid medical services. The need to adapt to various interfaces of medical clinic websites.

Valeria reviewed the factors influencing the structure of medical clinic websites, and used them to evaluate existing interfaces, as well as template solutions, which became the basis for developing a value proposition. A detailed marketing study was aimed at analyzing the target audience, namely its consumer preferences, needs, and ways of interacting with the medical website. Based on this, the information architecture of the digital resource was developed, as well as additional sections and functions that were implemented in the prototype.

Valeria then conducted a three-stage prototype testing, after which it became clear that the proposed structure and navigation were more user-friendly. In addition, patterns were identified in solving typical problems by people of different age groups. After that, the UI design of the main screen was developed, demonstrating the possibilities of adapting the prototype.

Thus, as a result of the study, the factors influencing the structure of the mobile version of medical sites were systematized, proposals were formed for designing an interface aimed at users from different age groups, and an animated prototype was developed that can be used as a template solution.

As Valeria notes, the results obtained have practical value for private medical organizations in St. Petersburg that are seeking to optimize their digital services.

This topic was chosen due to existing consumer problems, such as the need to adapt to different interfaces and the complexity of information perception, which were identified during the analysis of medical institution websites. I would like to express my gratitude for the contribution to the work to the scientific director Elena Valeryevna Knyazeva and scientific consultant Marina Borisovna Yanenko. I would like to express special gratitude to Maria Valeryevna Illarionova for supervising the stages of creating the architecture and UX design of the prototype, – said Valeria Rekina.

Three RINTS articles and a presentation at scientific conferences have been published on the topic of the research. This year, at the ISI Science Week, in the Design in Industry and Information Environment section, Valeria Rekina's development was awarded a first-degree diploma.

Please note: This information is raw content obtained directly from the source of the information. It is an accurate report of what the source claims and does not necessarily reflect the position of MIL-OSI or its clients.

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