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Students from the Institute of Civil Engineering at Peter the Great St. Petersburg Polytechnic University, led by ISI Associate Professors Maria Drebezgova and Alena Sheremet, and Assistant Victoria Pedenko, participated in the architectural design session "Molzavod: Starting Point," held in Gatchina. The workshop brought together leading experts in architecture, urban planning, cultural heritage preservation, and economics, practicing architects, and faculty and students from specialized St. Petersburg universities. Over the course of one day, the participants developed conceptual proposals for transforming the site and buildings into a modern cultural and social cluster.

The architectural session was organized by the Gatchina Municipal Administration and the ARCH-EVENT Association of Architects. The event, supported by the Council for Architecture and Urban Development of the Leningrad Region, the St. Petersburg Union of Architects, ALFRESCO and BERKANO, and the Leningrad Region Committee for Urban Development Policy, brought together teams from leading architectural universities in St. Petersburg: Peter the Great St. Petersburg Polytechnic University, St. Petersburg State University of Architecture and Civil Engineering, St. Petersburg Mining University of Empress Catherine II, and the St. Petersburg State Stieglitz Academy of Art and Design.

During the workshop, participants were tasked with conducting a comprehensive analysis of the site, including its historical and cultural context and current conservation regulations, and developing conceptual proposals for the functional content and architectural and spatial transformation of the site. Particular attention was paid to the methodology for working with industrial heritage, developing principles for careful reconstruction, and shaping a sustainable architectural vision.

The team leaders were Irina Barto, head of the Umbra architectural bureau; Tatyana Dmitrieva, head of the Formanorma architectural studio; Arseniy Mamoshin, chief architect of the Mamoshin architectural studio; and Evgeny Novosadyuk, architect and partner of the Studio 44 architectural bureau.

The expert evaluation of the projects was carried out by a council including representatives of government bodies of the Leningrad Region and the Gatchina Municipal District, as well as leading practitioners in the field of urban planning and architecture—members of the urban planning councils of St. Petersburg and the Leningrad Region and heads of architectural firms.

The team from the Higher School of Design and Architecture of the St. Petersburg Polytechnic University's Civil Engineering Institute successfully presented a concept for the development of the plant's territory and received a commendation from Igor Kulakov, Chairman of the Leningrad Region Committee for Urban Development Policy.

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Associate professors from the Higher School of Design and Architecture of the Civil Engineering Institute of Peter the Great St. Petersburg Polytechnic University, Elena Ladik and Maria Drebezgova, took part in the 10th All-Russian Forum "Barkamp 2025."

The forum's business program included an expert session, "The Arctic as a Breakthrough Scientific and Technological Project for Russia," dedicated to the strategic objectives of developing the Russian Federation's Arctic zone. Participants discussed key development areas for the region: enhancing its attractiveness as a place to live and work, creating sustainable social and engineering infrastructure, implementing advanced technologies, and mechanisms for government and industry support for the implementation of innovative projects.

Elena Ladik and Maria Drebezgova participated in the session, presenting innovative projects for the development of Arctic and Far North territories. Under their guidance, ISI Master's student Yulia Demyanyuk contributed to the development of project concepts for the development of the Arctic residential environment. ISI Master's students Alexandra Sudarikova and Ekaterina Falaleeva developed projects related to the development of Arctic and northern tourism.

In recent decades, interest in developing the Arctic and Far North has been growing worldwide. Developing the Arctic zone is one of the most pressing challenges for the Russian Federation and requires the creation of infrastructure and an architectural environment that takes into account regional characteristics. This year, together with master's students from the Higher School of Design and Architecture of the Civil Engineering Institute, we focused our design work on issues of organizing the architectural environment in harsh climates and the search for a regional identity for northern territories. We plan to continue working on this topic next year, shared Elena Ladik.

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Peter the Great St. Petersburg Polytechnic University held the 25th anniversary of its international scientific and practical conference, "Professional Culture of the Specialist of the Future." This year, the conference had a special status: the project's 25th anniversary coincided with the fifth anniversary of the international scientific journal, Technology and Language.

Natalia Chicherina, Director of the SPbPU Humanities Institute, opened the plenary session. She emphasized the conference's importance for the academic community. Having begun with the new millennium, the conference has provided an interdisciplinary and international platform for discussion, debate, and the advancement of new ideas for 25 years, serving as a bridge to the future.

The plenary session brought together scholars from Russia, China, Armenia, and Germany—specialists demonstrating the multifaceted humanities aspects of contemporary scientific and technological development and the education of specialists. A recurring theme of the conference was visualization as a way of thinking and representing.

The presentations by Dong Luo (South China University of Technology, Guangzhou) and Ervand Margaryan (Russian-Armenian University, Yerevan) demonstrated deep connections between cultural patterns and contemporary digital technological practices.

Alfred Nordmann, President of the International Society for Philosophy and Technology, demonstrated how visual similarity influences scientific theories and guides decision-making in complex technological systems and scientific research.

Alexander Nesterov, Director of the Humanities Institute at Samara National Research University named after Academician S. P. Korolev, demonstrated the importance of a philosophical understanding of technological development for technical specialists.

The conference's panels and roundtables showcased practical applications of visual practices in scientific, engineering, museum, and educational settings. The roundtable discussion "Visions and Views on Progress," featuring Chinese specialists from Shanxi University, South China University, and Shanghai University of Traditional Chinese Medicine, allowed for a comparison of Eastern and Western concepts of progress.

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The 5th Congress of Young Scientists featured a series of key events featuring the leadership and leading scientists of Peter the Great St. Petersburg Polytechnic University. The university's experts moderated and spoke at discussion panels on current scientific issues, including strategic partnerships, science diplomacy, global competitiveness, and the transformative role of artificial intelligence.

SPbPU First Vice-Rector and Corresponding Member of the Russian Academy of Sciences Vitaly Sergeev presented a successful model of collaboration at the "ObninskTech" session: "Partnership Creating Opportunities." In his speech, he outlined the university's mechanisms for effective collaboration with industrial companies and government agencies to address technological challenges.

We've moved away from abstract interaction. The mechanism we've built is project-oriented collaboration. We form consortia of scientists, graduate students, and engineers to address specific technological challenges facing industrial partners. The government's role in this model is to create regulatory and infrastructural "lifts" that allow for rapid progress from R&D to mass production. This is the formula for partnership that creates opportunities, commented Vitaly Sergeev.

Oleg Rozhdestvensky, Head of the SPbPU Office of Technological Leadership, participated in the discussion "Is Postgraduate Education Industrial or Production-Based? A New Concept for Training Highly Qualified Personnel?"

Participants discussed a large-scale overhaul of scientific training aimed at achieving technological sovereignty and ensuring Russia's scientific and technological leadership. The creation of new tracks in postgraduate studies that integrate fundamental science with industry challenges and enable the training of researchers capable of generating technologies, including those applied in practice. In this context, the speakers discussed how science and industry interact, the criteria used to differentiate postgraduate tracks, the changing dissertation defense procedures, and what makes the training attractive to future researchers.

Oleg Rozhdestvensky spoke about SPbPU launching a pilot industrial postgraduate program in 2025. As part of this project, a network agreement and a letter of intent were signed with PAO Tekhpribor. In his speech, the speaker highlighted key features of the postgraduate program, such as the presence of two supervisors: "The supervisor's job is to select a relevant topic and implement the developments, and practical experience should be valued above formal academic credentials."

In his speech, Oleg Rozhdestvensky focused on the issue of intellectual property and working with confidential information.

This is a stumbling block we still have to overcome. The key value of industrial postgraduate studies is building a foundation of mutual trust and shared achievements with the partner with whom we are launching the track, the speaker noted.

Polytechnic University's achievements in technological leadership will also be showcased in a new podcast series. "Aerobatics"Filming for the project began at the Congress of Young Scientists in Sochi. Oleg Rozhdestvensky, head of the university's Office of Technological Leadership, presented the university's experience.

International scientific and educational cooperation is also developing. Maxim Zalyvsky, Head of the SPbPU Project Office, moderated the discussion "Russia-Africa: Opportunities for Applied Research Projects," which focused on the practical aspects of implementing joint programs with African countries.

The university's achievements in this area are significant: SPbPU not only coordinates the work of the Russian-African Network University consortium but also serves as the lead implementer for developing a higher education transformation concept for its partners. The university actively works to export Russian educational standards, developing and adapting programs to the needs of African countries.

We see enormous potential in the synthesis of fundamental science and applied research. It is precisely these projects—from artificial intelligence to agricultural technology—that become a bridge for a long-term and mutually beneficial partnership between Russia and Africa," emphasized Maxim Zalyvsky.

The panel discussion "Global Competitiveness of Science: How to Ahead of the Curve?" addressed the positioning of Russian science on the global stage. Professor Irina Rudskaya, Director of the Gazprom Neft Scientific and Educational Center for IT and Business Analysis, presented her expert opinion: "The key metric in the new talent race is adaptability. Strategic investment in this skill allows economic systems to more effectively convert imbalances and crises into growth opportunities. Victory will go to those actors who focus on developing social intelligence, cognitive flexibility, and resilient institutions capable of rapid transformation."

The lively discussion, "Academic Supervisor: Boss, Coach, or Educator?" focused on the transformation of the mentor's role in today's scientific environment. Maria Vrublevskaya, SPbPU Vice-Rector for Human Resources Policy, participated.

A scientific supervisor is a triad: a scientist, a manager, and a mentor. It is this focus that enables a young scientist to successfully implement their research projects and objectives, noted Maria Vrublevskaya.

Ivan Zhdanov, head of the seismic project within the KNTN-3 program "Priority 2030," and Dmitry Bogdanov, director of the Gazpromneft-Polytech Scientific and Educational Center, spoke about practical cases of AI application in the oil and gas industry and the university's educational programs.

The speakers presented interim results of the development of AI engineering in oil and gas exploration. Particular emphasis was placed on the integration of intelligent systems into scientific processes.

"The Transformer architecture and neural network models dramatically accelerate the interpretation of geological data and improve the accuracy of digital field models," said Ivan Zhdanov.

AI is a catalyst that not only opens up new research opportunities but also transforms educational pathways, preparing specialists to work with the technologies of the future, concluded Dmitry Bogdanov.

Experts emphasized that it is the synergy between the Polytechnic University's fundamental science, applied research, and education that creates the foundation for the development of domestic technologies.

Furthermore, the Polytechnic University's stand showcased an interdisciplinary panorama of scientific research, demonstrating the convergence of various fields of knowledge. Young Polytechnic University researchers and invited speakers presented to participants of the 5th Congress of Young Scientists how fundamental developments in quantum artificial intelligence and spatial data processing are integrating with humanities research, forming a holistic ecosystem of scientific solutions.

Lilia Talipova, a senior lecturer at the Institute of Geosciences and Information Systems (ISI), presented a paper titled "Spatial Data for Scientific Research." The expert explained how spatial data allows us to see science "on the map"—to understand not only what is happening, but also where and why. It opens up access to satellite images, terrain models, and sensor data, transforming complex processes into visual stories. It's a tool that makes research more accurate, deeper, and more engaging.

Nikolai Ushakov, a professor at the Higher School of Physical and Computer Engineering and a leading researcher at the Fiber Optics Laboratory, presented a paper titled "Quantum Machine Learning. When Will We Get a Quantum ChatGPT and Why?" He analyzed the fundamental advantages of quantum computers over classical ones in solving complex computational problems.

The speaker focused on the prospects for the development of quantum computing and the resources required to achieve an advantage over existing large machine learning models: Quantum machine learning opens up fundamentally new possibilities for solving computational problems inaccessible to classical systems, but its practical implementation requires overcoming fundamental technological barriers.

Maxim Novikov, a senior lecturer at the Higher School of Social Sciences, presented his study, "Government Borrowing in the Post-War USSR: Economics, Efficiency, and Emotions." Using a grant from the Russian Science Foundation, he demonstrated the economic impact of government loans from 1946 to 1957 on Soviet citizens' budgets, the specifics of public reactions to these measures, and deviant behavior during campaigns.

Studying government loans in the post-war USSR through an interdisciplinary lens allows us to identify not only economic mechanisms but also their direct impact on everyday practices and the emotional state of citizens, emphasized Maxim Novikov.

Ekaterina Alekseeva, a leading researcher at the New Technologies and Materials Scientific and Technical Complex at the Institute of Metallurgical and Metallurgical Engineering, head of educational programs, and associate professor at the Higher School of Advanced Digital Technologies at the Central Institute of Metallurgical and Metallurgical Engineering, raised the pressing question: "Why do innovations take so long to reach the market, and how can they be accelerated?"

The speaker shared insights about barriers to commercializing developments and ways to overcome them: Reducing the time between scientific development and its market entry requires creating effective institutional bridges between the research environment and the real sector of the economy.

Also at the Congress of Young Scientists, the Association of Young Scientists and Student Scientific Societies of the Northwestern Federal District presented a project aimed at fostering dialogue between science and society. The "Lecturer Database" is an open platform that will help universities, museums, and other venues find speakers, and scientists gain new opportunities to promote their research.

The initiative addresses two key issues: organizers often lack contacts with scientists willing to discuss their work in accessible language, and the researchers themselves don't always know how to reach interested audiences. The new database will serve as a search and interaction tool for them.

The platform will allow you to filter lecturers by scientific disciplines, presentation topics, and geography, saving time in selecting the right candidate.

"The demand for high-quality scientific content is growing, but the infrastructure for its distribution is still not systematized," explains Maria Ganapolskaya, Chair of the Polytechnic University's Student Research Council. "Our goal is not just to connect with others, but to create a functioning ecosystem where the organizer will find a competent speaker, and the scientist will find their audience."

Among other things, the results of the Advanced Research Foundation's open competition were announced at the Congress. Anton Smirnov, a graduate student at St. Petersburg Polytechnic University, won with his project "Digital Avatars for the Northern Sea Route." He received preferential treatment for inclusion in the Advanced Research Foundation's talent pool, as well as the opportunity to implement his projects in accordance with the foundation's regulations as a commissioner of relevant research, forming the necessary cooperation and subsequently implementing the results.

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At the end of November, a representative of SPbPU took part in the International Conference "Congress of Users of the SKIF Center for Collective Use: Advanced Research Using Synchrotron Radiation," held in Akademgorodok, Novosibirsk.

The Siberian Ring Photon Source Shared Use Center (SKIF) is a generation 4 synchrotron radiation (SR) source being built in the Koltsovo science city near Novosibirsk. The SKIF accelerator complex consists of a 200 MeV electron linear accelerator, a 3 GeV booster synchrotron, and a storage ring. The 3 GeV relativistic electron storage ring, with a perimeter of 476 m and an ultra-low calculated horizontal emittance of 73.2 pcm rad, will deliver SR beams with a peak brightness in the range from 10 eV to 100 keV to 30 experimental stations. For photon energies of ~1.5 keV, the source emittance approaches the wave (diffraction) limit, ensuring a high degree of SR coherence, which expands the potential of the research complex. The SKIF Center for Collective Use's infrastructure will be used to conduct world-class research in various fields of physics, chemistry, materials science, molecular biology, medicine, and other disciplines, with an emphasis on the most breakthrough, economically and socially significant multidisciplinary tasks.

The congress provides a broad discussion platform and a meeting place for representatives of the SKIF Center for Collective Use, developers of unique scientific equipment, and future users. The congress program included plenary lectures, oral and poster presentations, and roundtable discussions on "SKIF Center for Collective Use Stations" and "Organizational Aspects of SKIF Center for Collective Use Work."

Professor of the Higher School of Engineering and Physics and Advisor to the Rector's Office of SPbPU Alexey Filimonov spoke at the round table "Organizational Aspects of the SKIF Center for Collective Use," where issues of organizing and planning work on the devices were discussed.

A few days earlier, Alexey Filimonov delivered a plenary talk at the international scientific conference "Instrument Engineering-2025" in Minsk, organized by the Belarusian National Technical University with the participation of the National Academy of Sciences of the Republic of Belarus. The topic of the talk, "The Effect of Electric Field on Phase Transitions in PZT Solid Solutions," was directly related to the theme of the SKIF congress, as the scientific results presented in it were obtained using synchrotron sources using the SR scattering method.

Antiferroelectrics, particularly lead zirconate and lead zirconate titanate-based solid solutions (PZT, PbZr(1-x)TixO3) with a low lead titanate content, are the best-known antiferroelectrics and are of interest in the development of fast capacitor-type electrical energy storage devices and electrocaloric cooling systems. The existence of so-called antiphase domain walls (APDWs) in pure lead zirconate has recently been experimentally demonstrated. APDWs in antiferroelectrics are flat domain walls several nanometers wide with nonzero polarization. These structures have proven to be of great interest as the basis for nonvolatile memory devices with ultrahigh data recording density. This paper examines the influence of electric fields on phase transitions in PZT and the possibility of controlling the domain structure of the antiferroelectric phase.

The conference brought together over 600 delegates from nine countries. Following successful negotiations with representatives of leading Belarusian universities (BSU, BNTU, and BSUIR), an agreement was reached to conduct joint research, and a draft proposal for a joint project was prepared.

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On November 27, a plenary session entitled "Big Challenges: Impetus for Development" was held at the Sirius University of Science and Technology. The event, timed to coincide with the 80th anniversary of Russia's nuclear industry, brought together leading experts in science and technology. Andrey Rudskoy, Rector of Peter the Great St. Petersburg Polytechnic University, participated in the session.

The meeting discussed strategic directions for the development of Russian science and the role of the nuclear industry in the country's technological sovereignty. Participants paid particular attention to training personnel for high-tech industries and developing scientific infrastructure. St. Petersburg Polytechnic University has traditionally been a key source of personnel for the nuclear and other industries, and the university's research finds application in various sectors of the economy.

"The Congress of Young Scientists is an important platform for shaping the scientific agenda," noted the SPbPU rector. "Participation in such events allows us not only to stay abreast of the latest trends but also to assess the prospects for integrating university science into solving major technological challenges."

At the Polytechnic University stand, Rector Andrey Rudskoy discussed projects presented by the Student Scientific Society (SSS) and the Council of Young Scientists (CYS) with students, postgraduate students, and young scientists.

These initiatives need to be developed and boldly brought to the implementation stage. The future of science belongs to you: students, graduate students, and young researchers. Your energy and innovative approach are the main resource for scientific discoveries," the university's director encouraged the young innovators.

The Student Research Community provides students with their first research experience, putting their academic theories to the test. The Council of Young Scientists is a community of graduate students, engineers, and researchers under 35 who not only conduct their own projects but also help their colleagues apply for grants, organize scientific seminars, and coordinate interdisciplinary work.

During the Congress of Young Scientists, the Polytechnic University's stand brought together projects where fundamental science addresses specific challenges facing industry and society, and became a platform for open dialogue where young scientists discussed their projects and promising ideas.

Polytechnicians and invited speakers demonstrated how their research influences development in a wide range of fields, from energy to history.

Oleg Shmakov, Associate Professor at the Higher School of Automation and Robotics at the Institute of Mechanical Engineering, Materials, and Transport and project manager for the Priority 2030 program, presented a robotic system for gas pipeline diagnostics.

"The length of our main pipelines exceeds 170,000 kilometers," the scientist explained. "The robots we've developed allow for their effective monitoring, preventing accidents."

Irina Anikina, Associate Professor at the Institute of Power Engineering's Higher School of Nuclear and Thermal Energy, demonstrated how digital technologies are transforming the industry. Her team is creating digital twins of power equipment that "learn" from sensor data.

These models don't just describe an asset; they account for its wear and tear in real time. This allows for predicting breakdowns and optimizing repair schedules, Anikin noted.

Konstantin Semenov, Associate Professor at the Higher School of Computer Technology and Information Systems at the Institute of Computer Science and Cybersecurity, proposed examining the very nature of measurement. His paper, "Absolutely Precise Measurements Are a Coarsening of Reality," explores how error affects our understanding of the world and why striving for perfect accuracy can be a simplification.

Zoya Korobova, Chair of the Council of Young Scientists at the Pasteur Research Institute of Epidemiology and Microbiology in St. Petersburg and a researcher in the Laboratory of Molecular Immunology, discussed the new role of the immune system.

Today, we see that immunity is not just a protector, but a key regulator of most processes in the body. Studying it opens up new possibilities for treating a wide range of diseases, the researcher said.

Natalia Morozova, Associate Professor at the Institute of Biomedical Systems and Biotechnology, Higher School of Biotechnology and Food Production, presented a paper titled "Tools and Methods of Genome Editing," highlighting the current opportunities and challenges in this rapidly developing field. She also detailed examples of successful applications of CRISPR-Cas technologies to address challenges in biotechnology and medicine.

Ekaterina Pchitskaya, Head of the Biomedical Image and Data Analysis Laboratory at the Institute of Cardiology and Biophysics, presented a paper titled "Artificial Intelligence for Studying the Natural: Synapses, Neural Networks, and Behavior." The scientist demonstrated how machine learning methods can decipher complex processes occurring in the nervous system and link neuronal activity to behavioral events.

Tatyana Koryakovtseva, Associate Professor at the Higher School of Hydraulic and Power Engineering at the Civil Engineering Institute, conducted a study on the concrete of the future. Scientists are incorporating synthetic and natural materials into traditional concrete to create stronger and warmer building composites. The project includes an environmental assessment of the materials, enabling the selection of not only effective but also sustainable solutions.

Ilya Sidorchuk, a professor at the Higher School of International Relations at the Humanities Institute, took the audience into the world of suburban science.

"The history of suburbs helps us understand how modern urban life was shaped," the professor believes. "By studying the everyday lives of residents, we see that the city is a complex organism where the interests of people, government, and nature are intertwined."

Lyudmila Dorofeeva, Senior Researcher at the Institute of Regional Economic Problems of the Russian Academy of Sciences and Chair of the Council of Young Scientists and Specialists, spoke about the practical implementation of these developments. She presented a unique continuing education program, "Qualified Customer – Qualified Contractor," which Polytechnic University is implementing in collaboration with academic and industrial partners.

We train specialists who are able to intelligently set scientific goals and understand how to apply their results in the real sector, Dorofeeva explained.

The Polytechnic University's scientific program, presented at the stand, demonstrates how the university creates an environment where engineering solutions, historical analysis, and biomedical research combine to offer answers to complex modern challenges.

Recognized experts also spoke at the Polytechnic University stand: Corresponding Member of the Russian Academy of Sciences Nikolai Kuznetsov and biotechnology specialist Youssef Khesuani.

Nikolai Kuznetsov presented the theory of hidden oscillations—a branch of nonlinear dynamics that allows for the detection of hidden threats in complex engineering systems. Unlike classical oscillations, hidden attractors do not manifest near equilibrium points, making them particularly dangerous. A system can maintain apparent stability for years until a random impact triggers a catastrophic failure.

"Hidden oscillations are not an abstract concept, but a real engineering problem," noted Professor Kuznetsov. "We've learned to detect them before they lead to accidents. Our theory helps prevent power system failures and improves flight safety."

The theory received practical confirmation during the analysis of the accident at the Sayano-Shushenskaya Hydroelectric Power Plant. The methods are already being used in projects with RusHydro and the Elektropribor Central Research Institute, demonstrating that fundamental mathematics is becoming a key tool for ensuring the safety of complex technical systems.

Yusef Khesuani discussed modern advances in 3D bioprinting—a technology for layer-by-layer fabrication of tissue constructs based on digital models. He focused on practical aspects, such as the need for careful selection of printing conditions and subsequent growth of the constructs in bioreactors.

The uniqueness of our collagen solutions lies in their ability to work with cells without neutralizing acidity and their high biocompatibility after implantation, the researcher explained.

The technology is already demonstrating successful use cases, from eardrum repair to the creation of custom-made ear implants. Its future lies in the development of invasive methods that allow printing directly into the damaged area.

Both speakers noted the special role of the Polytechnic University as an integrator of science and practice.

"This is a unique platform where fundamental theory meets real-world challenges," concluded Nikolai Kuznetsov. "It's here that high-tech solutions in demand by the real economy are developed."

Yusef Khesuani added: "Young researchers from the Polytechnic University are renowned for their work, ranging from the creation of new materials to medical diagnostic systems. Seeing such motivated scientists among the audience and exchanging ideas with them creates a unique creative atmosphere."

The Polytechnic's stand confirmed the university's status as a center for interdisciplinary scientific collaborations and the creation of technologies that define the country's technological sovereignty.

The participation of Polytechnic University leadership in the Congress of Young Scientists demonstrated the university's active role in shaping the country's scientific and technological policy and its readiness to implement ambitious projects in partnership with leading research centers and industrial enterprises.

The Polytechnic University serves as a key link between academic research and the real sector. Polytechnic researchers' research in new materials, energy, and digital technologies is directly applied by Russian enterprises. This strengthens the country's technological sovereignty and competitiveness.

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Scientists from Peter the Great St. Petersburg Polytechnic University have developed a new dosage form with encapsulated antitumor compounds for use in the oral treatment of both primary and metastatic melanoma. The researchers synthesized nanoparticles from biocompatible and biodegradable polymers—gelatin (GNPs) and chitosan (ChNPs)—loaded with the therapeutic compound. Research has shown that the nanoparticles help the compound maintain its integrity while passing through the aggressive environment of the human gastrointestinal tract. This allows for maximum effectiveness in oral targeted cancer therapy. The study results were published in the International Journal of Biological Macromolecules.

According to research, melanoma is one of the most aggressive cancers with high metastatic activity. Metastases are the main cause of death in melanoma patients. Standard chemotherapy protocols typically use cytostatic and cytotoxic drugs to destroy cancer cells. However, this approach also has the side effect of destroying healthy cells. A new, modern method is targeted therapy, which destroys only tumor cells. Currently, more than 150 targeted compounds have been approved for the targeted therapy of various oncological diseases. The use of these drugs offers advantages over traditional chemotherapy, as they reduce toxicity to healthy tissue and minimize side effects. Scientists are developing both new, effective drugs and methods for improving their bioavailability.

Researchers are currently studying the efficacy of targeted small-molecule drugs, such as PARP (poly(ADP-ribose) polymerase) inhibitors, in melanoma treatment. Despite their effectiveness, their use is limited by their pharmacokinetics. The main problem with existing PARP inhibitors is their low oral bioavailability. The acidic environment, enzymes, and other biological barriers of the gastrointestinal tract degrade the drug, requiring high doses and reducing its effectiveness.

Scientists from the Institute of Biomedical Systems and Biotechnology at Peter the Great St. Petersburg Polytechnic University focused on creating an effective dosage form for PARP inhibitors that would allow the compounds to maintain their integrity in the gastrointestinal tract. The researchers synthesized nanocarriers based on biocompatible and biodegradable polymers—gelatin (GNPs) and chitosan (ChNPs). These nanoparticles encapsulated a PARP inhibitor synthesized by the study's authors, based on substituted 2-aminothiophene (2AT) derivatives.

In experiments on mice with a solid melanoma model, oral administration of the compound using the new dosage forms resulted in tumor growth suppression by 88–95% compared to the control group. In a model of metastatic melanoma with lung lesions, the nanoformulations of the drug demonstrated an 82% suppression of metastasis formation, noted Sergey Shipilovskikh, PhD in Chemistry and leading researcher at the Laboratory of Nano- and Microencapsulation of Biologically Active Substances at SPbPU.

Using bioimaging techniques (SPECT and fluorescence imaging), scientists have documented that the nanoparticles, after oral administration, effectively accumulate and remain for a long time in the gastrointestinal tract (stomach, small intestine, and colon). This confirms their ability to overcome gastrointestinal barriers and deliver the drug to its target. Studies including histological analysis of organs and blood biochemistry revealed no serious adverse effects from the new dosage forms. The drugs demonstrated a good safety profile.

"Our study demonstrates that encapsulating a PARP inhibitor in gelatin and chitosan nanoparticles increases its bioavailability and therapeutic efficacy when administered orally. This approach allows for effective treatment of not only the primary tumor but also metastases, which is critical for melanoma treatment," noted Anna Rogova, a research assistant at the Laboratory of Nano- and Microencapsulation of Biologically Active Substances at SPbPU and a postgraduate student in Biophysics.

The developed strategy opens up new prospects for the creation of effective and safe oral drugs for targeted therapy of oncological diseases.

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On November 26, the 5th Congress of Young Scientists opened at the Sirius University of Science and Technology. Its program covered key areas of Russia's scientific and technological development. This federal-level event brought together international formats, including the BRICS Forum on Social Sciences and Humanities, strategic sessions on major challenges, and practical tracks for supporting scientific personnel.

Peter the Great St. Petersburg Polytechnic University presented a comprehensive research development program and cutting-edge technological developments at the congress. The Polytechnic's exhibition program focused on integrating young researchers into the scientific community, building their careers, and mastering science popularization tools. The program included both applied career workshops and presentations of cutting-edge fundamental research.

The university's showcase centered on a development in additive manufacturing—a system for multi-material laser 3D printing with metals. This technology enables the creation of products with fundamentally new properties by combining various metal alloys in a single production cycle. This method opens up possibilities for synthesizing materials with gradient properties unachievable using traditional methods.

Visitors to the exhibition will see examples of promising applications of the technology using specific case studies:

In medicine, this involves the creation of bimetallic implants, where a high-strength titanium alloy is combined with a more biocompatible one, allowing for the control of mechanical properties and integration with bone tissue; in the aerospace and energy industries, this involves the production of bimetallic combustion chambers with an inner wall made of heat-resistant bronze and an external reinforcing contour made of nickel alloys; in mechanical engineering, this involves the manufacture of lightweight parts with high thermal conductivity due to the combination of aluminum and copper, as well as products with a shape memory effect based on nitinol with a variable composition.

The technology, which allows for the "stitching" of different metal alloys into a single product, generated keen interest among visitors to the stand.

"For me, as someone who studies biocompatible coatings, a bimetallic implant isn't just a component, but a philosophical approach to regenerative medicine," shared Anna Kovaleva, a postgraduate student in the Department of Materials Science at Bauman Moscow State Technical University. "The ability to locally alter mechanical properties, creating a gradient from rigid to more elastic bone tissue, is a step toward personalized implants of the future. I saw here a tangible embodiment of ideas we've only read about in scientific papers."

"The demonstration of a bimetallic combustion chamber is a response to one of the key 'grand challenges' in my field," added Dmitry Samokhin, a young energy scientist from TPU. "The combination of heat resistance and strength in a single component, manufactured in a single cycle, radically changes the design approach. This isn't just an evolution in manufacturing; it's a revolution in engineering, allowing us to look beyond the capabilities of traditional materials."

The equipment presented by Polytechnic University scientists is equipped with two laser sources with a power of up to 1000 W and allows simultaneous work with four different materials in a print zone with a diameter of 150 mm and a height of 220 mm.

Another key exhibit was the Snegir family of unmanned aerial vehicles (UAVs), created by the Digital Engineering experimental design bureau of the Advanced Engineering School of SPbPU. This project exemplifies the implementation of the end-to-end digital engineering paradigm. The vehicles were designed from scratch in record time—five months—using the university's proprietary CML-Bench® digital platform, allowing them to refine the methodology for creating digital twins.

The latest model, the Snegir-2, was presented at the congress. It is an unmanned aerial vehicle with a 3.5-meter wingspan and a takeoff weight of 25 kg. Its key features include increased stability due to improved aerodynamics and control systems, as well as a modular architecture that allows for quick adaptation for various missions. The UAV is capable of carrying a payload of up to 8 kg, reaching speeds of up to 200 km/h, and covering distances of up to 200 km. This development has formed the basis for the creation of specialized platforms for digital UAV design and certification.

The Snegir family of unmanned aerial vehicles, created using end-to-end digital engineering, has become a clear example of how university science is responding to the demands of the times.

"I was impressed not so much by the Snegir-2 model itself, but by the methodology," said Ilya Petrenko, a graduate student and aerodynamicist from Ural Federal University, a visitor to the Polytechnic University booth. "Creating an aircraft from scratch in five months is a colossal feat. The CML-Bench® platform is essentially a ready-made toolkit for us, researchers. It removes the barrier between fundamental science and applied development, allowing us to quickly verify hypotheses in a virtual environment, saving months of work and resources."

A project aimed at solving socially significant problems is the universal tracked platform "Zhuchok." This development provides freedom of movement for people with disabilities in difficult terrain and off-road conditions.

The platform boasts excellent cross-country capability: it can climb inclines of up to 35 degrees and navigate snow, sand, and mud. With a curb weight of 100 kg and a speed of up to 10 km/h, the "Zhuchok" provides a range of at least 10 km. The design features a low center of gravity, high maneuverability, and low noise. Its key feature is a universal mount that allows the platform to be used with most wheelchair models, making the technology accessible to a wide range of users.

The universal tracked platform "Zhuchok" demonstrated that high technology serves not only industry, but also the solution of pressing social problems.

"At these conferences, people often talk about breakthroughs in IT or energy, but 'Zhuchok' is an example of science with a human face," says Marina Semenova, a biophysics graduate student at MIPT. "The simplicity and versatility of the solution are key factors for its implementation. A low center of gravity and low noise are more than just performance characteristics; they are well-thought-out engineering solutions that directly impact human comfort and safety. Projects like these motivate you to pursue science because you see the direct impact of your work—improving someone's life."

The Polytechnic University's booth served as the epicenter of a lively, informal exchange. The lecture program opened with a series of events aimed at the professional development of young scientists. Applicants to the doctoral program were able to undergo a quick assessment of their admission chances and received a personalized "roadmap" from university experts.

In the interactive session "Career Paths of Postgraduate Students," successful young scientists from the Polytechnic University shared their experiences building a scientific career at the university. A report on the activities of the Student Scientific Society (SSS) was also presented, titled "From the Organization of the SSS to the Grant: Victories and Mistakes." Participants learned about best practices for attracting students to science and organizing the SSS at SPbPU, using the example of a grant received from the Russian Ministry of Education and Science.

The program continued with motivational speeches and master classes. Nikita Blagoy (IPMET) led the session "Aftershocks of Science: Navigating the Universe of Possibilities," and Kristina Shikhirina (HSE University – St. Petersburg) presented a step-by-step guide to popularizing science for student scientific fellows and young scientists' councils, focusing on effectively bringing science popularization projects to fruition.

The audience was incredibly engaged. We explored case studies on how to package complex research into understandable and viral content. It's important that young Polytechnic University scientists see popularization not as a hobby, but as a professional skill that helps attract funding and partners," noted Natalia Leontieva, Head of the SPbPU Office for Support of Research Projects and Programs.

A keynote address on the program was given by a representative of the Laboratory for Advanced Methods of Spherical Tokamak Plasma Research. Laboratory research assistant Arseny Tokarev delivered a report titled "Thermonuclear Technologies: Developing Key Competencies and Talent in the SPbPU Youth Laboratory." The scientist highlighted the Polytechnic University's contribution to one of the most important areas of global science—controlled thermonuclear fusion research. The speaker also touched on the training of a new generation of researchers for work on major Russian and international facilities, including the ITER project and the tokamak reactor technology.

"Our goal isn't simply to conduct experiments on tokamaks. We're developing a talent pool for the ITER project and future fusion reactors," Arseniy explained. "When I spoke to colleagues from other venues about our work, we discussed not abstract prospects, but the specific engineering problems that need to be solved. The congress demonstrated that a strong, close-knit community of young scientists is emerging in Russia, ready to tackle the most ambitious tasks together."

The booth's work will conclude on the first day of the congress with an interactive quiz hosted by the "Science at Polytechnic" Student Scientific Society. Participants will take three rounds of questions on the history of science, modern laboratories, and student initiatives.

The quiz and lively discussions prove that science is not just strict formulas but also a vibrant, engaging community. The SPbPU booth became a micromodel of the entire congress: a place where not only ideas are born but also professional connections that shape the future of Russian and global science.

The SPbPU program, as part of a large-scale federal event, demonstrates a comprehensive approach to training scientific personnel—from assistance with admission to graduate school and the development of soft skills to engaging young people in solving global scientific and technological problems—supported by demonstrations of high-tech developments.

The first day of the congress demonstrated its interdisciplinary nature and broad thematic scope. Dozens of parallel sessions focused on addressing "grand challenges." Participants discussed the role of artificial intelligence as a scientific tool, the prospects for fusion energy, bioprinting of organs and tissues, and the pharmaceuticals of the future. A separate section was devoted to science diplomacy, including a session on the legacy of the International Physicians for the Prevention of Nuclear War movement.

Considerable attention was paid to supporting research at all stages. The Russian Science Foundation (RSF) held a series of events, "RSF School," where young scientists learned about the rules for submitting grant applications for fundamental and applied research and were introduced to the Foundation's review system. The practical component was enhanced by sessions dedicated to the commercialization of developments and the transformation of scientific ideas into successful startups, with the support of development institutions such as Gazprombank and Rosselkhozbank.

The 5th Congress of Young Scientists, which opened on November 26, confirmed its status as the main federal platform for dialogue between science, government, and society. But behind the large-scale strategic sessions and international formats are real people—young researchers for whom the congress has become a focal point for ideas and career trajectories.

Please note: This information is raw content obtained directly from the source. It represents an accurate account of the source's assertions and does not necessarily reflect the position of MIL-OSI or its clients.

Translation. Region: Russian Federation –

Source: Peter the Great St. Petersburg Polytechnic University –

An important disclaimer is at the bottom of this article.

The Institute of Industrial Management, Economics, and Trade hosted an extended meeting of the Council on Labor Productivity and Operational Efficiency of the Association of Industrial Enterprises of St. Petersburg (APP SPb), held jointly with the Regional Competence Center of St. Petersburg. The Graduate School of Industrial Management of IPMEIT organized the meeting on behalf of the university.

The Council meeting was opened by Alexander Gromov, CEO of the Association of Industrialists and Entrepreneurs of St. Petersburg, who addressed the participants with a welcome address from Valery Radchenko, President of the Association: "I am confident that our joint work, combining the experience of industrialists, the knowledge of scientists, and the expertise of industry associations, will enable us to develop concrete recommendations and find practical solutions to the most pressing challenges. I wish us all fruitful work, constructive dialogue, and useful contacts!"

Vladimir Glukhov, SPbPU Rector's Advisor, addressed the participants on behalf of the university. He noted the importance of holding such meetings, as well as the university's commitment to serious engagement with employers and active educational activities in partnership with the real sector to train highly qualified specialists for St. Petersburg's economic sectors.

IPMET Deputy Director Arkady Evgrafov wished all participants productive work, lively discussions, and the development of practical solutions and recommendations.

Over 60 representatives from industrial enterprises and organizations attended the meeting. The main objective was to discuss best practices for applying digital technologies in HR at industrial enterprises in our city, as well as improving productivity and employee retention through innovative and highly productive workflow processes. In addition to association members, representatives from HR companies actively implementing digital and IT solutions in their HR practices were invited to the meeting.

Khamit Fattakhov, Chairman of the Council of the Association of Industrialists and Entrepreneurs of St. Petersburg on Labor Productivity and Operational Efficiency, Head of the Digital Transformation Program at JSC Cordiant, and Associate Professor at the Higher School of Industrial Management at St. Petersburg Polytechnic University, opened the discussion. He set the tone for the discussion by examining HR practices in the digital transformation of production systems as drivers of increased labor productivity.

Digital transformation isn't just about new digital tools; it's also about a new era in the development of production systems and labor relations. It requires a different approach to employee engagement, one focused on understanding their individuality and needs, and their engagement in production processes. We review best practices and examples of such transformations at our council, noted Khamit Fattakhov.

The co-presenter was Kristina Gavrilina, head of the analytics group at Power Machines JSC.

Fyodor Dmitriev, Director of Operational Efficiency at the Regional Center for Labor Productivity Competencies, presented a report entitled "Lean Personnel Development: From Theory to Practice."

Yulia Efimova, Commercial Director of the St. Petersburg branch of Perviy BIT, discussed specialized automation maps and key digitalization trends in the industrial sector.

Olga Kalinina, Director of the Higher School of Industrial Management, presented a review report, jointly prepared with Olga Ergunova, Associate Professor at the Higher School of Industrial Management. The report focused on HR strategies for developing personnel, increasing their productivity, and retaining key specialists based on data analysis, process automation, and digital culture at enterprises.

Vladimir Kvach, Head of the Production Systems Development Department at Nevsky Zavod JSC, shared Nevsky Zavod's experience in organizing rationalization activities. His co-presenter was Mikhail Kamenev, a young specialist at the plant and a student at the Higher School of Industrial Management, who successfully completed his internship last year and found employment at the plant. He is also currently a first-year master's student. Mikhail discussed his practical work related to equipment monitoring, loss analysis, and motivating operators to improve machine efficiency.

Veronika Akulova, Director of the HR Automation and Electronic Document Management Department at IBS Group, presented practical examples of how digital technologies can be used in HR to motivate, manage burnout, and increase employee engagement.

The final presentation was a discussion of flexible platform HR models and practical recommendations for using these forms of employment, presented by Natalia Berdyeva, Development Director at SkillStaff.

At the end of the meeting, Sergei Belfer, Advisor to the Association of Chambers of Commerce and Industry of St. Petersburg, summarized the presentations by all speakers. The event concluded with an informal discussion, during which new contacts were established and future areas of cooperation were discussed.

Please note: This information is raw content obtained directly from the source. It represents an accurate account of the source's assertions and does not necessarily reflect the position of MIL-OSI or its clients.

Translation. Region: Russian Federation –

Source: Peter the Great St. Petersburg Polytechnic University –

An important disclaimer is at the bottom of this article.

The All-Russian scientific and practical conference with international participation, "State Transformation in a Digital Society: New Management Solutions and Security Challenges," was held at Peter the Great St. Petersburg Polytechnic University. It was timed to coincide with the 10th anniversary of the Institute of Industrial Management, Economics, and Trade. The conference was organized by the Higher School of Public Administration. Key events included plenary and breakout sessions, a roundtable discussion, a discussion platform, and a business simulation.

The event opened with a plenary session, bringing together government experts, young professionals, and students interested in developing public and municipal services in the context of digital transformation. Leading public administration experts spoke at the plenary session.

Igor Murashev, Deputy Chairman of the Committee on Civil Service and Personnel Policy of the St. Petersburg Governor's Administration, presented a report entitled "Trends in the Development of the State Civil Service in St. Petersburg." He highlighted key changes, current challenges, and prospects for the development of the regional civil service.

Today, we are faced with the task of discussing key trends in the development of the civil service in the context of digitalization. Modern professionals are confronted with two opposing trends: on the one hand, the blurring of specializations, and on the other, the growing need for broad expertise and peripheral knowledge. To be in demand, you need to become unique to employers, develop your own competencies, and be able to see the big picture. It's important to be focused, see your projects through to completion, differentiate yourself from others, and understand the industry average to stay just above it. I wish everyone productive work and interesting discussions! noted Igor Murashev.

Andrey Zhabrev, head of the Polyustrovo municipality and First Deputy Chairman of the Council of Municipalities of St. Petersburg, spoke about the dynamics of local government in the city. In his speech, he noted that a new system of unified public authority is being formed, which improves governance and accountability, facilitates the integration of the municipal level into the citywide system, and ensures an equally high quality of life for all residents. According to him, this is an important step forward, allowing government bodies to work more effectively with the public and respond more quickly to their requests.

The future depends on each of you—on your attitude to work, your desire to make a difference, and your love for your homeland and region. It's important that your work is always rooted in your heart, soul, and understanding of what you do and why. Today, a new system of unified public authority is being formed, enhancing governance and accountability, integrating municipalities into the citywide system, and ensuring a uniform quality of life for all residents. This will improve the effectiveness of government bodies and their interactions with the public. You are studying at one of the oldest and best universities in the country—take advantage of this opportunity, learn from strong professors whose experience and service to society are a true foundation for future success. It's important to choose a direction that resonates with you and pursue it to the end. Be proactive, take initiative, and believe in yourself," shared Andrey Zhabrev.

Participants also found particular interest in the discussion panel "Public Service Without a Tie," held in the Posnikov Conference Hall. The panel was moderated by Igor Murashev and Maxim Ivanov, Deputy Director of the Institute of Industrial Management, Economics, and Trade.

Polytechnic University graduates, members of the Youth Personnel Reserve, and young civil servants took part in the open dialogue:

Ekaterina Makareikina, Chief Specialist of the Civil Service and Personnel Department of the Construction Committee; Yulia Katrashova, Lead Specialist of the Small and Medium Entrepreneurship Support Department of the Entrepreneurship Development Department of the Committee for Industrial Policy, Innovation, and Trade of St. Petersburg; and Ekaterina Evlampieva, Chief Specialist of the Vocational Education Department of the Education Committee.

The discussion focused on the most pressing issues for young professionals: how to enter the civil service through the Youth Personnel Reserve, what career opportunities are available in executive bodies, what the workday of a civil servant looks like, what challenges young professionals face, what skills are most in demand, how management decisions are made, and how responsibility is distributed at different levels.

Participants emphasized that it is important for modern civil servants to possess not only professional knowledge, but also flexible thinking, responsibility, and a willingness to continuously develop.

Yulia Katrashova, a 2025 graduate of the HSE Master's program, offered advice to future professionals: "You're just at the beginning of your journey. Find your field, develop, and don't be afraid of anything!"

The event was broadcast online, significantly expanding the audience for the discussion and making the discussion of public administration issues accessible to all interested parties.

The conference also included a roundtable discussion, "Serving the City: New Quality of Training for Government Personnel," moderated by HSSU associate professors Marina Ivanova and Tamara Selentyeva.

The roundtable brought together representatives of government agencies from St. Petersburg and the Leningrad Region, federal authorities, representatives of the country's regions, heads of state and municipal institutions and enterprises, and university experts. Issues related to university-government cooperation, ensuring the quality of training for public sector personnel, and experience in implementing successful joint projects were discussed.

Marina Ivanova emphasized: "The importance of such events is difficult to overestimate; it is obvious both to government agencies and, of course, to the university. Direct, open dialogue, aligned positions, and visions on providing graduates with in-demand competencies are what allow education to remain relevant, effective, and meaningful. The dialogue generated numerous new ideas and challenges for jointly ensuring the quality of training for future civil servants."

The roundtable brought together true professionals in training personnel for the civil service and municipal government. During the discussions, potential employers of our graduates raised questions about the necessary skills and abilities required of young professionals. We, on the academic side, listened to their opinions and developed a collaboration strategy to implement these plans. "I hope that next year we will be able to present the first results of the updated student training format in a similar format," shared Grigory Kulkaev, a participant in the roundtable and Deputy Director for Practical Training at HSE University.

A business game, "Elections: Candidate," was organized for conference participants. It was led by Varvara Bucherova, Deputy Chair of the St. Petersburg Youth Parliament and a 2025 graduate of the Graduate School of Public Administration (HSSU), and Nikita Golubov, representative for youth affairs of the Kalininsky District Administration of St. Petersburg. The game helped improve political literacy and understanding of the election process.

The conference consisted of three sections.

Current Trends in Public and Municipal Administration. Moderator: Victoria Degtereva, Professor, Graduate School of Public Administration. Public and Municipal Management of Socioeconomic and Environmental Development. Moderator: Natalia Putintseva, Associate Professor, Graduate School of Public Administration. Regional Economic Security: Current Challenges, Threats, and Opportunities for Improving the Effectiveness of Interagency Cooperation in the Digital Environment. Moderator: Tatyana Feofilova, Associate Professor, Graduate School of Public Administration.

During the sections, participants shared important research findings and discussed topics in the areas of public and municipal governance and economic security.

"We have gathered here to discuss how public authority is changing under the onslaught of digital technologies, what new competencies are required of civil servants, and how to ensure security in this rapid process, as economic security is becoming the foundation upon which state resilience, its technological sovereignty, and the well-being of citizens are built. Modern threats are complex: from cyberattacks on critical infrastructure to new challenges in global markets. And it is the quality of our management decisions and the effectiveness of interdepartmental cooperation in the digital environment that determines whether we can not only counter these threats but also transform them into new opportunities for development," said Olga Nadezhda, Acting Director of the Graduate School of Management.

The event became an important platform for scientific and professional dialogue, exchange of experience, and the development of new ideas in the field of public administration.

Please note: This information is raw content obtained directly from the source. It represents an accurate account of the source's assertions and does not necessarily reflect the position of MIL-OSI or its clients.