Translation. Region: Russian Federal
Source: Novosibirsk State University –
An important disclaimer is at the bottom of this article.
From September 24th to 26th, the 26th All-Russian Scientific and Educational Forum "Mother and Child"—the most significant annual event for all obstetricians and gynecologists in the country—was held in Moscow. The forum brought together 5,600 specialists in person and 6,800 online from 226 cities and 13 countries, including Russia. Current issues in obstetrics and gynecology, gynecological endocrinology, perinatology, reproductive medicine, pediatric and adolescent gynecology, ultrasound, and laboratory diagnostics were discussed daily in the forum's 10 halls.
Novosibirsk State University and the Professor Pasman Clinic, a long-standing partner of the university, prepared three presentations:
1. Pre-pregnancy preparation, management of pregnancy and childbirth with a history of recurrent thrombosis (Pasman N.M., Drobinskaya A.N., Dudareva A.V., Shaklein A.V., Rogov N.V., Wagner Yu.N., Dmitrieva O.V., Kolesnikova A.V., Pis'mak M.A.) – together with the team of the maternity hospital of the 1st City Clinical Hospital.
2. Extragenital forms of endometriosis. Surgical treatment. Prevention of relapses (Kramskoy V.G., Sokolov A.V., Pasman N.M., Veretelnikova T.V.) — in collaboration with the 1st City Clinical Hospital.
3. Asherman's syndrome: diagnosis, treatment, pre-pregnancy preparation (Veretelnikova T.V., Pasman N.M., Pronicheva S.V., Selyunina N.A.).
Also speaking at the forum on behalf of NSU and the Regional Clinical Hospital was Alla Drobinskaya, Head of the Regional Perinatal Center, Chief Anesthesiologist-Resuscitator in Obstetrics, PhD, Associate Professor in the Department of Obstetrics and Gynecology at the Institute of Medicine and Medical Technologies at NSU. Her presentation was titled "HELLP Syndrome from the Perspective of an Obstetric Anesthesiologist."
At the traditional competition for young scientists, held as part of the Forum in English, the results of a 6th-year student's research were presented. Institute of Medicine and Medical Technologies of NSU Sofia Shiffon "Transcriptome analysis of stage-dependent molecular changes in endometriosis of various localizations."
The research was conducted at Professor Pasman's Clinic, using endoscopic procedures performed by Tatyana Vladimirovna Veretelnikova, and in the Cell Technologies Laboratory of the Research Institute of Fundamental and Clinical Immunology (RIFI). The research was supervised by Elena Removna Chernykh, MD, Professor, Corresponding Member of the Russian Academy of Sciences, and Deputy Director of RIFI. A total of 100 applications were submitted to the competition, and Sofia Shiffon's work took third place.
In our work at the Cellular Immunotherapy Laboratory at the Research Institute of Physical Culture, Infection, and Clinical Infection, we comprehensively examined molecular changes in endometriosis—a chronic gynecological inflammatory disease—at various stages. In our experimental work, we studied how patients' peritoneal fluid influences the phenotype of immune cells. We also conducted a multiplex analysis of 27 cytokines in the peritoneal fluid, identifying specific biomarkers for each stage.
My task was to supplement these experimental data with a bioinformatics experiment: transcriptomic (histology sequencing) profiling of endometriosis tissues. I analyzed 408 samples from 162 patients using differential gene expression and coexpression network construction. This allowed me to identify molecular changes occurring at different stages and locations of endometriosis, as well as validate the data obtained in the laboratory experiment," explained Sofia Shiffon.
Endometriosis affects approximately 10% of women of reproductive age, but is diagnosed on average 7-10 years after the onset of symptoms. Endometriosis symptoms significantly impair patients' quality of life. Existing hormonal therapy is not effective for all patients, and after surgical treatment, the recurrence rate reaches 40-50% within five years.
This study, conducted by NSU in collaboration with Professor Pasman's Clinic and the Research Institute of Physical Infection and Clinical Clinical Infections, opens up new possibilities for targeted immunotherapy, minimally invasive diagnostics, and provides new insights into the mechanisms of disease development.
Speaking about the success factors that enabled her to win the competition, Sofia noted that the key was the integrative approach, which combined several levels of analysis: from functional experiments with living cells to bioinformatic analysis of the transcriptome and the identification of biomarkers in biological fluids.
"The use of network analysis (WGCNA) allowed us to identify not individual genes, but functional modules reflecting key pathophysiological processes—from lesion implantation to metabolic adaptation and immune escape. Importantly, the results have clear translational potential: they point to specific therapeutic targets and biomarkers that can be validated for clinical use. Undoubtedly, the scientific supervision of Elena Removna Chernykh and Natalia Mikhailovna Pasman also played a decisive role. Thanks to them, I mastered the methods of systems immunology and learned to connect fundamental research with the clinical practice of a gynecologist," emphasized Sofya Shiffon.
Congratulations to Tatyana Vladimirovna, who represented NSU and the clinic with dignity, on her brilliant performance, and to Sofia Shiffon on her victory. We wish them continued creative success!
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