Translation. Region: Russian Federal
Source: Peoples'Friendship University of Russia –
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The project to develop a cellular model of the placenta won in the Scientific Materials category of the Young Scientists 3.0 competition, organized with the support of the Presidential Grants Fund and T-Bank.
The research team is developing a technology for modeling pregnancy pathologies and testing transplacental transport in vitro – “Placenta-on-a-chip”.
"Using microfluidic technology, we recreated a three-layer model of the placenta, repeating the structure of the chorionic villus, containing trophoblast cells, macrophages and endothelial cells. Previously, such models included only two types of cells, which did not quite reflect the real physiology of the organ and the important role of the immune system for its normal functioning. Microfluidic technologies appeared as a revolutionary achievement in the field of biomedicine, transforming the approach to modeling the physiology of individual human organs and cellular analysis of the processes occurring in them. These technologies use channels with sizes in the micrometer range to manipulate small volumes of liquids, which allows, by simulating the blood flow in the organ, to observe complex biological interactions in vitro," – Olga Lazareva, researcher at the Laboratory of Molecular Pathophysiology of the Research Institute of Molecular and Cellular Medicine of the RUDN Medical Institute.
Modeling pregnancy pathologies on the developed placenta-on-a-chip, if not eliminating, then complementing the expensive preclinical stage of testing on model laboratory animals and the clinical stage of testing on patients, which is often impossible in the case of pregnant women.
Also read about the development in Izvestia by link.
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