Translation. Region: Russian Federal
Source: Novosibirsk State University –
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The results of the Russian Science Foundation mega-grant competition for fundamental scientific research and exploratory scientific research under the supervision of leading foreign scientists have been summed up. 230 projects from 127 scientific organizations from 35 subjects of the Russian Federation applied for RSF support. The projects submitted for the competition are being implemented under the supervision of leading scientists with citizenship from 40 countries, including China, India, Iran, Belarus, Kazakhstan, the USA, Italy, and France. According to the results of the examination, 14 projects were declared winners. For 5 years, they will receive from 20 to 50 million rubles annually. If necessary, it is envisaged to extend the grant support for another three years.
Among the winners is the project of scientists from the Laboratory of Nonlinear Optics of Waveguide Systems of Novosibirsk State University "The Kerr Self-Cleaning Effect of Multimode Beams in Specialized Optical Fibers and Its Application for Biomedicine". This laboratory was created in May 2017 as a result of the victory of the project "Spatio-temporal Nonlinear Optics of Multimode and Multi-Core Fiber Systems" in the fifth competition of the Ministry of Education and Science of Russia for receiving grants from the Government of the Russian Federation for state support of scientific research conducted under the supervision of leading scientists. Its head is a recognized world expert in the theory of surface waves, as well as an expert in nonlinear effects in fiber-optic communication systems Stefan Wabnitz. His research activity for more than 30 years took place in leading academic and industrial institutions in Europe and the USA.
— Our project is aimed at creating an innovative endoscopic device that combines optical biopsy and low-temperature plasma therapy technologies. Its goal is to develop a unified system that provides the ability to both diagnose and treat gastrointestinal diseases, including oncological diseases, in real time, which will eliminate the need for lengthy histopathology and increase the accuracy of examinations. This device will combine two functions at once — diagnostics (using machine learning) and therapy (laser/plasma), minimizing damage to healthy tissues, — said Denis Kharenko, senior researcher at the laboratory.
In current medical practices, ex vivo histopathology is used for accurate cancer diagnostics, during which laboratory studies of living tissue transferred from the body to an artificial external environment are carried out. It involves taking tissue from the patient, which leads to delays in the start of therapy and requires complex laboratory procedures and practically does not allow observing the course of the disease in dynamics. NSU scientists propose to solve this problem by introducing in-vivo diagnostics, which allows examining the body without taking material using optical endoscopic methods. It is important that this diagnostic method will be associated with the possibility of therapeutic intervention, which will not only significantly increase the area under study and the volume of data obtained, but also accurately identify the affected area during repeated examination, minimizing time and economic costs, as well as the risks of errors associated with the analysis of samples outside the body.
— The new type of endoscopic system we are creating, in addition to diagnostics, will be able to precisely affect tumor cells using temperature-controlled laser radiation and low-temperature plasma, causing their apoptosis without excessive heating — a process of programmed cell death, in which the cell self-destructs, disintegrating into individual fragments, which are then absorbed by other cells without causing negative consequences. This leads to minimal damage to healthy tissue. This feature will reduce side effects, avoid fibrosis and vascular damage, which is extremely important for improving the quality of life of patients. The project is a significant step forward in the field of "optical biopsy" and endoscopic therapy, — explained Denis Kharenko.
One of the main scientific tasks of the scientists will be to optimize the process of diagnostics and treatment of cancer using a multimode optical fiber, which implements the Kerr self-cleaning effect, providing high resolution (up to 0.66 µm) and resistance to mechanical impacts during the propagation of laser radiation. The integration of multiphoton fluorescence and Raman scattering will further expand the diagnostic capabilities of the device, allowing for spectroscopic studies of tissues and the detection of biomarkers characteristic of different stages of the disease with microscopic accuracy. According to the project participants, this technology will make the device a universal tool for both diagnostics and subsequent treatment.
The project involves several stages. First, the scientists will design and test multimode fibers and high-repetition-rate lasers for the endoscopic system. The next step will be to test the device on biological samples, including lab-created organoids and cancerous tissue.
— We are confident that our experimental setup with the ability to precisely control low-temperature plasma will allow localized impact on the affected areas of organs and tissues, which will create the basis for the application of the technology in clinical practice. We intend to create a flexible and highly effective visualization and therapy system, which will subsequently become established as a standard in the field of diagnostics and treatment of gastrointestinal diseases, including oncological diseases in the early stages, — said Denis Kharenko.
Material prepared by: Elena Panfilo, NSU press service
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